Mouse ACY1 Recombinant Protein (RPPB5784)

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SKU:
RPPB5784
Product type:
Recombinant Protein
Size:
10ug
Species:
Mouse
Target:
ACY1
Synonyms:
Aminoacylase-1
Synonyms:
ACY-1
Synonyms:
N-acyl-L-amino-acid amidohydrolase
Synonyms:
Aminoacylase 1
Source:
Escherichia Coli
Uniprot:
Q99JW2
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Description

Product Name:Mouse ACY1 Recombinant Protein
Product Code:RPPB5784
Size:10µg
Species:Mouse
Target:ACY1
Synonyms:Aminoacylase-1, ACY-1, N-acyl-L-amino-acid amidohydrolase,Aminoacylase 1, Acy1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:ACY1 protein solution (0.25mg/ml) containing Phosphate buffered saline (pH7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSEFMTTKD PESEHPSVTL FRQYLRICTV QPNPDYGGAI TFLEERARQLGLSCQKIEVV PGFVITVLTW PGTNPSLPSI LLNSHTDVVP VFKEHWHHDP FEAFKDSEGY IYARGSQDMK SVSIQYLEAVRRLKSEGHRF PRTIHMTFVP DEEVGGHKGM ELFVKRPEFQ ALRAGFALDE GLANPTDAFT VFYSERSPWWVRVTSTGKPG HASRFIEDTA AEKLHKVISS ILAFREKERQ RLQANPHLKE GAVTSVNLTK LEGGVAYNVVPATMSASFDF RVAPDVDMKA FEKQLQRWCQ EAGEGVTFEF AQKFTEPRMT PTDDSDPWWA AFSGACKAMN LTLEPEIFPAATDSRYIRAV GIPALGFSPM NRTPVLLHDH NERLHEDIFL RGVDIYTGLL SALASVPTLP GES

Acy1or Aminoacylase1 is a cytosolic, homodimeric, zinc-binding enzyme whichcatalyzes the hydrolysis of acylated L-amino acids to L-amino acids and acylgroup, and has been suggested to operate in the catabolism and salvage ofacylated amino acids. ACY1 is localizedin chromosome 3p21.1, a regionreduced to homozygosity in small-cell lung cancer (SCLC), and its expressionhas been observed to be reduced or undetectable in SCLC cell lines and tumors.

ACY1 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 433 amino acids (1-408 a.a) and having a molecular mass of 48.4kDa. ACY1 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:ACY1: Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate). Defects in ACY1 are the cause of aminoacylase-1 deficiency (ACY1D). ACY1D results in a metabolic disorder manifesting with encephalopathy, unspecific psychomotor delay, psychomotor delay with atrophy of the vermis and syringomyelia, marked muscular hypotonia or normal clinical features. Epileptic seizures are a frequent feature. All affected individuals exhibit markedly increased urinary excretion of several N-acetylated amino acids. Belongs to the peptidase M20A family.Protein type: Amino Acid Metabolism - arginine and proline; EC 3.5.1.14; HydrolaseChromosomal Location of Human Ortholog: 9 F1|9 57.49 cMMolecular Function: aminoacylase activity; zinc ion bindingBiological Process: peptide catabolic process; proteolysis
UniProt Protein Details:
NCBI Summary:
UniProt Code:Q99JW2
NCBI GenInfo Identifier:449784892
NCBI Gene ID:109652
NCBI Accession:NP_001263371.1
UniProt Secondary Accession:Q99JW2,Q9CR15
UniProt Related Accession:Q99JW2
Molecular Weight:45,781 Da
NCBI Full Name:aminoacylase-1
NCBI Synonym Full Names:aminoacylase 1
NCBI Official Symbol:Acy1  
NCBI Official Synonym Symbols:Acy-1; 1110014J22Rik  
NCBI Protein Information:aminoacylase-1
UniProt Protein Name:Aminoacylase-1
UniProt Synonym Protein Names:N-acyl-L-amino-acid amidohydrolase
Protein Family:Aminoacylase
UniProt Gene Name:Acy1  
UniProt Entry Name:
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