cGAS-STING Pathway Antibody Sampler Pack

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SKU:
ABSP030
Product Type:
Antibody
Size:
Antibody Sampler Pack
Size:
8 X 20μL
Reactivity:
Human
Mouse
Rat
Analytes:
cGAS
STING
Phospho-STING
TBK1
Phospho-TBK1
IRF7
Phospho-IRF3
IFI16
  • Anti-cGAS Antibody (CAB8335)
  • Anti-STING Antibody (CAB20175)
  • Anti-Phospho-STING/TMEM173-S366 [ARC57910] Monoclonal Antibody (CABP1369)
  • Anti-TBK1/NAK Antibody (CAB2573)
  • Anti-Phospho-TBK1/NAK-S172 [ARC1571] Monoclonal Antibody (CABP1026)
  • Anti-IRF7 Antibody (CAB0159)
  • Anti-Phospho-IRF3-S386 [ARC1539] Monoclonal Antibody (CABP0995)
  • Anti-IFI16 Antibody (CAB14002)

Description

cGAS-STING Pathway Antibody Sampler Pack

The cGAS-STING Pathway Antibody Sampler Pack from Assay Genie brings together 8 rigorously validated antibodies spanning the key nodes of this pathway, supplied in a convenient 20µL trial size. It lets researchers screen an entire signalling axis in a single, cost-effective pack — validated for applications including ELISA, IF/ICC, IHC-P, WB — before committing to full-size vials. Each antibody is also available individually in a full 100µL size.

TargetAntibodyCat. No.HostReactivityApplicationsSize
cGASAnti-cGAS AntibodyCAB8335-20RabbitHuman, Mouse, RatWBIHC-PIF/ICCELISA20µL
STINGAnti-STING AntibodyCAB20175-20RabbitHuman, Mouse, RatWBIHC-PELISA20µL
Phospho-STINGAnti-Phospho-STING/TMEM173-S366 [ARC57910] Monoclonal AntibodyCABP1369-20RabbitHumanWBELISA20µL
TBK1Anti-TBK1/NAK AntibodyCAB2573-20RabbitHuman, Mouse, RatWBIHC-PELISA20µL
Phospho-TBK1Anti-Phospho-TBK1/NAK-S172 [ARC1571] Monoclonal AntibodyCABP1026-20RabbitHuman, MouseWBELISA20µL
IRF7Anti-IRF7 AntibodyCAB0159-20RabbitMouseWBELISA20µL
Phospho-IRF3Anti-Phospho-IRF3-S386 [ARC1539] Monoclonal AntibodyCABP0995-20RabbitHumanWBELISA20µL
IFI16Anti-IFI16 AntibodyCAB14002-20RabbitHuman, Mouse, RatWBIHC-PELISA20µL

The cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING) pathway is a central cytosolic DNA-sensing system that detects pathogen-derived and aberrant self DNA to mount type I interferon and inflammatory responses. cGAS is a nucleotidyltransferase that binds double-stranded DNA in the cytosol in a sequence-independent manner; DNA binding induces a conformational change that activates its catalytic site to synthesize the cyclic dinucleotide second messenger 2'3'-cGAMP. This messenger binds and activates STING, an endoplasmic reticulum-resident adaptor, triggering its oligomerization and trafficking to the Golgi. Activated STING, marked by phosphorylation (Phospho-STING), serves as a signaling scaffold that recruits the kinase TBK1. TBK1 undergoes activating autophosphorylation (Phospho-TBK1) and in turn phosphorylates the transcription factor IRF3; Phospho-IRF3 then dimerizes and translocates to the nucleus, where, together with IRF7 in amplification loops, it drives transcription of type I interferons and interferon-stimulated genes. STING also engages NF-kB signaling to induce additional inflammatory mediators. A related DNA sensor, IFI16, recognizes nuclear and cytosolic DNA and can cooperate with the cGAS-STING axis to promote interferon responses and inflammasome activation. This pathway is essential for antiviral and antibacterial immunity and for immunosurveillance of tumors, where it can prime antitumor T-cell responses, but chronic activation by self DNA, as in certain interferonopathies and autoimmune diseases, is pathogenic. Consequently, both STING agonists and inhibitors are being pursued therapeutically. Tracking activation requires reagents distinguishing total and phosphorylated forms of the key signaling nodes. This sampler pack brings together validated antibodies against cGAS, STING, Phospho-STING, TBK1, Phospho-TBK1, IRF7, Phospho-IRF3, and IFI16 for studying cytosolic DNA sensing and cGAS-STING signaling.

AnalyteAlternate Names
cGASMB21D1, cGAS, Cyclic GMP-AMP synthase, C6orf150
STINGSTING1, TMEM173, MITA, ERIS, MPYS
Phospho-STINGSTING1, TMEM173, STING (phospho-Ser366)
TBK1TANK-binding kinase 1, NAK, T2K
Phospho-TBK1TBK1, TANK-binding kinase 1 (phospho-Ser172)
IRF7Interferon regulatory factor 7
Phospho-IRF3IRF3, Interferon regulatory factor 3 (phospho-Ser396)
IFI16Interferon gamma inducible protein 16, IFNGIP1, PYHIN2
SpecificationDetail
Pack Format8 antibodies, 20µL each (trial size)
StorageStore at -20°C upon receipt
Shelf Life12 months from date of receipt
ShippingGel pack
Scale-upEvery antibody is also available individually in a full 100µL size

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