Anti-DNA/RNA Damage Antibody [15A3]

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SKU:
STMA00034
SKU:
STMA00034
Antibody Type:
Monoclonal
Applications:
IHC
ICC/IF
ELISA
DB
IP
FCM
FA
Reactivity:
Species Independent
Host Species:
Mouse
Isotype:
IgG2b

Description

DNA/RNA Damage Antibody [15A3]

DNA/RNA Damage Antibody [15A3] is a mouse monoclonal antibody directed against DNA/RNA Damage, offered by Assay Genie for research applications. Reported applications include IHC, ICC/IF, ELISA, DB, IP, FCM and FA. Reactivity is species independent. Supplied as IgG2b, purified by Protein G.

DNA and RNA damage are critical molecular events that contribute to the onset and progression of neurodegenerative diseases. These lesions arise from both endogenous metabolic processes and environmental stressors, including oxidative stress, inflammation, and exposure to neurotoxins. In neurons—cells with limited regenerative capacity—such damage can have profound and lasting effects. Reactive oxygen and nitrogen species (RONS), such as hydroxyl radicals and peroxynitrite, induce oxidative modifications to nucleic acids. Key biomarkers of this damage include 8-hydroxyguanine (8-OHG), 8-hydroxy-2'-deoxyguanosine (8-OHdG), and 8-hydroxyguanosine (8-OHG), which are associated with mutagenic base transversions and impaired transcriptional fidelity. These lesions disrupt gene expression, mitochondrial function, and synaptic signaling—hallmarks of neurodegenerative pathology. In diseases such as Alzheimer’s, Parkinson’s, and ALS, persistent DNA and RNA damage activates neuroinflammatory pathways and accelerates neuronal loss. Moreover, the failure of DNA repair mechanisms exacerbates genomic instability, further compromising neural integrity. Understanding the molecular signatures of nucleic acid damage offers valuable insights into disease mechanisms and provides a foundation for developing diagnostic biomarkers and targeted therapies aimed at preserving genomic stability and neuronal function. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.

Product Name:DNA/RNA Damage Antibody [15A3]
Product SKU:STMA00034
Size:100 µg
Target:DNA/RNA Damage
Host Species:Mouse
Antibody Type:Monoclonal
Clone ID:15A3
Research Areas:Cancer, Oxidative Stress, Cell Signaling, Post-translational Modifications, Oxidation, Cell Signaling, Epigenetics and Nuclear Signaling, DNA/RNA, DNA Damage and Repair
Buffer:PBS, 50% glycerol, 0.09% sodium azide *Storage buffer may be subject to change
Storage & Shipping:Store at -20°C. Shipped on Blue Ice or 4°C. Conjugated variants should be stored according to the product label.
Format:Liquid
Applications:IHC, ICC/IF, ELISA, DB, IP, FCM, FA
Antibody Isotype:IgG2b
Purification:Protein G Purified
Concentration:1 mg/ml
Reactivity:Species Independent
Recommended Dilution:IHC (1:1000); optimal dilutions for assays should be determined by the user.
Specificity:Recognizes markers of oxidative damage to DNA (8-hydroxy-2'-deoxyguanosine, 8-hydroxyguanine and 8-hydroxyguanosine).
Guarantee:12 months from date of dispatch
Immunogen:8-hydroxy-guanosine-BSA and –casein conjugates
Alternative Names:8-Hydroxy Guanine, 8-OH-dG, 8OHG, 80G, 8-hydroxyguanine, 8-hydroxy-2'-deoxyguanosine, 8-hydroxyguanosine, 8 OHG, 8-OHG, 8OHdG
References:1. Kim H.W., Murakami A., Williams M.V., and Ohigashi H. (2003) Carcinogenesis 24(2): 235-241. 2. Pilger A. and Rudiger H.W. (2006) Int Arch Occup Environ Health. 80(1): 1-15. 3. Malins D.C. and Haimanot R. (1991) Cancer Res. 51(19): 5430-5432. 4. Kvam E. and Tyrrell R.M. (1997) Carcinogenesis 18(11): 2281-2283. 5. Kowluru R.A., Atasi L., and Ho Y.S. (2006) Invest Ophthalmol Vis Sci 47(4): 1594-9. 6. Bowers R. et al. (2004) Am J Respir Crit Care Med. 169(6): 764-9. 7. Cui J., Holmes E.H., Greene T.G., and Liu P.K. (2000) Faseb J. 14(7): 955-67.
Note:For research use only.

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