Anti-Cytokeratin 6 (KRT6) Antibody (CAB4631)

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SKU:
CAB4631
Product type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CK-6C
Synonyms:
CK-6E
Synonyms:
CK6A
Synonyms:
CK6C
Synonyms:
CK6D
Synonyms:
K6A
Synonyms:
K6C
Synonyms:
K6D
Synonyms:
KRT6C
Synonyms:
KRT6D
Synonyms:
PC3
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Description

Product Name:Cytokeratin 6 (KRT6) Rabbit mAb
Product Code:CAB4631
Size:20uL, 50uL, 100uL
Synonyms:CK-6C, CK-6E, CK6A, CK6C, CK6D, K6A, K6C, K6D, KRT6C, KRT6D, PC3
Applications:WB, IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human Cytokeratin 6 (KRT6) (KRT6)
Applications:WB, IHC
Recommended Dilutions:WB 1:1000 - 1:3000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:5637, A-431
Immunogen:A synthesized peptide derived from human Cytokeratin 6 (KRT6) (KRT6)
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:3853
Uniprot:P02538
Calculated MW:60kDa
Observed MW:60KDa
UniProt Protein Function:K6a: a type II cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Associates with K16 and/or -17.
UniProt Protein Details:

Protein type:Cytoskeletal

Chromosomal Location of Human Ortholog: 12q13.13

Cellular Component: membrane; keratin filament; nucleus

Molecular Function:protein binding; structural constituent of cytoskeleton

Biological Process: wound healing; positive regulation of cell proliferation; morphogenesis of an epithelium; cell differentiation

Disease: Pachyonychia Congenita 3

NCBI Summary:The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. In addition, peptides from the C-terminal region of the protein have antimicrobial activity against bacterial pathogens. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Oct 2014]
UniProt Code:P02538
NCBI GenInfo Identifier:1346344
NCBI Gene ID:3853
NCBI Accession:P02538.3
UniProt Related Accession:P02538
Molecular Weight:60kDa
NCBI Full Name:Keratin, type II cytoskeletal 6A
NCBI Synonym Full Names:keratin 6A
NCBI Official Symbol:KRT6A  
NCBI Official Synonym Symbols:K6A; K6C; K6D; PC3; CK6A; CK6C; CK6D; CK-6C; CK-6E; KRT6C; KRT6D  
NCBI Protein Information:keratin, type II cytoskeletal 6A
UniProt Protein Name:Keratin, type II cytoskeletal 6A
UniProt Synonym Protein Names:Cytokeratin-6A; CK-6A; Cytokeratin-6D; CK-6D; Keratin-6A; K6A; Type-II keratin Kb6; Allergen: Hom s 5
UniProt Gene Name:KRT6A  
UniProt Entry Name:K2C6A_HUMAN
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