Anti-Cytokeratin 16 (KRT16) 항체

Anti-Cytokeratin 16 (KRT16) Antibody (CAB8690)

(No reviews yet) Write a Review

제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.

주문

SKU:

CAB8690

Product type:

Antibody

Antibody Type:

Monoclonal Antibody

Reactivity:

Human

Reactivity:

Mouse

Reactivity:

Rat

Host Species:

Rabbit

Isotype:

IgG

Synonyms:

CK16

Synonyms:

FNEPPK

Synonyms:

K16

Synonyms:

K1CP

Synonyms:

KRT16A

Synonyms:

NEPPK

Synonyms:

PC1

Description

Description

UniProt Protein Function:	K16: a type I cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K6. K16 and K17 are coexpressed only in pathological situations such as metaplasias and carcinomas of the uterine cervix and in psoriasis vulgaris.
UniProt Protein Details:	Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 17q21.2 Cellular Component: cytoskeleton; intermediate filament; nucleus Molecular Function:protein binding; structural constituent of cytoskeleton Biological Process: keratinocyte differentiation; cell proliferation; epidermis development; keratinization; morphogenesis of an epithelium; intermediate filament cytoskeleton organization and biogenesis; innate immune response; cytoskeleton organization and biogenesis; inflammatory response; negative regulation of cell migration; keratinocyte migration; hair cycle; aging Disease: Palmoplantar Keratoderma, Nonepidermolytic, Focal; Pachyonychia Congenita 1
NCBI Summary:	The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region of chromosome 17q12-q21. This keratin has been coexpressed with keratin 14 in a number of epithelial tissues, including esophagus, tongue, and hair follicles. Mutations in this gene are associated with type 1 pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus. [provided by RefSeq, Jul 2008]
UniProt Code:	P08779
NCBI GenInfo Identifier:	23503075
NCBI Gene ID:	3868
NCBI Accession:	P08779.4
UniProt Secondary Accession:	P08779,P30654, Q16402, Q9UBG8, A8K488,
UniProt Related Accession:	P08779
Molecular Weight:	473
NCBI Full Name:	Keratin, type I cytoskeletal 16
NCBI Synonym Full Names:	keratin 16
NCBI Official Symbol:	KRT16
NCBI Official Synonym Symbols:	K16; PC1; CK16; K1CP; NEPPK; FNEPPK; KRT16A
NCBI Protein Information:	keratin, type I cytoskeletal 16; CK-16; keratin-16; cytokeratin 16; cytokeratin-16; focal non-epidermolytic palmoplantar keratoderma
UniProt Protein Name:	Keratin, type I cytoskeletal 16
UniProt Synonym Protein Names:	Cytokeratin-16; CK-16; Keratin-16; K16
Protein Family:	Keratin
UniProt Gene Name:	KRT16
UniProt Entry Name:	K1C16_HUMAN

View AllClose