Anti-Cytokeratin 12 (KRT12) Antibody (CAB19284)

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SKU:
CAB19284
Product type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
KRT12
Synonyms:
K12
Synonyms:
keratin 12
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Description

Product Name:Cytokeratin 12 (KRT12) Rabbit mAb
Product Code:CAB19284
Size:20uL, 50uL, 100uL
Synonyms:KRT12, K12, keratin 12
Applications:WB, IHC, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human Cytokeratin 12 (KRT12) (KRT12).
Applications:WB, IHC, IF
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Rat eye
Immunogen:Recombinant protein of human Cytokeratin 12 (KRT12) (KRT12).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:3859
Uniprot:Q99456
Calculated MW:54kDa
Observed MW:54KDa
UniProt Protein Function:K12: May play a unique role in maintaining the normal corneal epithelial function. Together with KRT3, essential for the maintenance of corneal epithelium integrity. Defects in KRT12 are a cause of Meesmann corneal dystrophy (MECD); also abbreviated MCD and known as juvenile epithelial corneal dystrophy of Meesmann. MECD is an autosomal dominant disease that causes fragility of the anterior corneal epithelium. Patients are usually asymptomatic until adulthood when rupture of the corneal microcysts may cause erosions, producing clinical symptoms such as photophobia, contact lens intolerance and intermittent diminution of visual acuity. Rarely, subepithelial scarring causes irregular corneal astigmatism and permanent visual impairment. Histological examination shows a disorganized and thickened epithelium with widespread cytoplasmic vacuolation and numerous small, round, debris-laden intraepithelial cysts. Belongs to the intermediate filament family.
UniProt Protein Details:

Protein type:Cytoskeletal

Chromosomal Location of Human Ortholog: 17q12

Biological Process: visual perception

Disease: Corneal Dystrophy, Meesmann

NCBI Summary:KRT12 encodes the type I intermediate filament chain keratin 12, expressed in corneal epithelia. Mutations in this gene lead to Meesmann corneal dystrophy. [provided by RefSeq, Jul 2008]
UniProt Code:Q99456
NCBI GenInfo Identifier:2497269
NCBI Gene ID:3859
NCBI Accession:Q99456.1
UniProt Secondary Accession:Q99456,B2R9E0,
UniProt Related Accession:Q99456
Molecular Weight:53,511 Da
NCBI Full Name:Keratin, type I cytoskeletal 12
NCBI Synonym Full Names:keratin 12
NCBI Official Symbol:KRT12  
NCBI Official Synonym Symbols:K12  
NCBI Protein Information:keratin, type I cytoskeletal 12
UniProt Protein Name:Keratin, type I cytoskeletal 12
UniProt Synonym Protein Names:Cytokeratin-12; CK-12; Keratin-12; K12
Protein Family:Keratin
UniProt Gene Name:KRT12  
UniProt Entry Name:K1C12_HUMAN
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