UniProt Protein Function: | ZNF274: Probable transcription repressor. Specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin- modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression. Belongs to the krueppel C2H2-type zinc-finger protein family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Nucleolus; DNA-binding; C2H2-type zinc finger protein; Transcription factorChromosomal Location of Human Ortholog: 19qterCellular Component: centrosome; nucleusMolecular Function: neurotrophin p75 receptor binding; protein binding; sequence-specific DNA binding; transcription corepressor activity; transcription factor activityBiological Process: regulation of transcription, DNA-dependent |
UniProt Protein Details: | |
NCBI Summary: | This gene encodes a zinc finger protein containing five C2H2-type zinc finger domains, one or two Kruppel-associated box A (KRAB A) domains, and a leucine-rich domain. The encoded protein has been suggested to be a transcriptional repressor. It localizes predominantly to the nucleolus. Alternatively spliced transcript variants encoding different isoforms exist. These variants utilize alternative polyadenylation signals. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q96GC6 |
NCBI GenInfo Identifier: | 327478548 |
NCBI Gene ID: | 10782 |
NCBI Accession: | Q96GC6.2 |
UniProt Secondary Accession: | Q96GC6,Q53XU4, Q6MZG1, Q8WY37, Q8WY38, Q92969, Q9UII0 Q9UII1 |
UniProt Related Accession: | Q96GC6 |
Molecular Weight: | 42,448 Da |
NCBI Full Name: | Neurotrophin receptor-interacting factor homolog |
NCBI Synonym Full Names: | zinc finger protein 274 |
NCBI Official Symbol: | ZNF274 |
NCBI Official Synonym Symbols: | ZF2; HFB101; ZSCAN51; ZKSCAN19 |
NCBI Protein Information: | neurotrophin receptor-interacting factor homolog |
UniProt Protein Name: | Neurotrophin receptor-interacting factor homolog |
UniProt Synonym Protein Names: | Zinc finger protein 274; Zinc finger protein HFB101; Zinc finger protein with KRAB and SCAN domains 19; Zinc finger protein zfp2; Zf2 |
Protein Family: | Neurotrophin receptor-interacting factor |
UniProt Gene Name: | ZNF274 |
UniProt Entry Name: | ZN274_HUMAN |