Type I / II Interferon Antibody Sampler Pack

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SKU:
ABSP027
Product Type:
Antibody
Size:
Antibody Sampler Pack
Size:
8 X 20μL
Reactivity:
Human
Mouse
Rat
Analytes:
RIG-I / DDX58
IRF7
IRF9
STAT1
STAT2
ISG15
IFITM3
OAS3
  • Anti-Rig-I/DDX58 [ARC54110] Monoclonal Antibody (CAB22478)
  • Anti-IRF7 Antibody (CAB0159)
  • Anti-IRF9 Polyclonal Antibody (CAB21331)
  • Anti-STAT1 [ARC0042] Monoclonal Antibody (CAB19563)
  • Anti-STAT2 [ARC51796] Monoclonal Antibody (CAB3588)
  • Anti-ISG15 [ARC53794] Monoclonal Antibody (CAB2416)
  • Anti-IFITM3 Antibody -Knockout Validated (CAB13070)
  • Anti-OAS3 Antibody (CAB9481)

Description

Type I / II Interferon Antibody Sampler Pack

The Type I / II Interferon Antibody Sampler Pack from Assay Genie brings together 8 rigorously validated antibodies spanning the key nodes of this pathway, supplied in a convenient 20µL trial size. It lets researchers screen an entire signalling axis in a single, cost-effective pack — validated for applications including ChIP-seq, ELISA, IF/ICC, IHC-P, IP, WB — before committing to full-size vials. Each antibody is also available individually in a full 100µL size.

TargetAntibodyCat. No.HostReactivityApplicationsSize
RIG-I / DDX58Anti-Rig-I/DDX58 [ARC54110] Monoclonal AntibodyCAB22478-20RabbitHuman, MouseWBELISA20µL
IRF7Anti-IRF7 AntibodyCAB0159-20RabbitMouseWBELISA20µL
IRF9Anti-IRF9 Polyclonal AntibodyCAB21331-20RabbitHumanWBELISA20µL
STAT1Anti-STAT1 [ARC0042] Monoclonal AntibodyCAB19563-20RabbitHuman, Mouse, RatWBIPChIP-seqELISA20µL
STAT2Anti-STAT2 [ARC51796] Monoclonal AntibodyCAB3588-20RabbitHuman, RatWBELISA20µL
ISG15Anti-ISG15 [ARC53794] Monoclonal AntibodyCAB2416-20RabbitHuman, Mouse, RatWBIF/ICCELISA20µL
IFITM3Anti-IFITM3 Antibody -Knockout ValidatedCAB13070-20RabbitHuman, Mouse, RatWBIHC-PIF/ICCELISA20µL
OAS3Anti-OAS3 AntibodyCAB9481-20RabbitHuman, Mouse, RatWBIHC-PIF/ICCELISA20µL

Interferons are a family of cytokines that constitute a principal arm of antiviral defense and immunoregulation, coordinating cell-intrinsic resistance to infection and shaping adaptive immunity. The response begins with cytosolic sensing of viral nucleic acids. The RNA helicase RIG-I/DDX58 detects short, blunt-ended, and 5'-triphosphorylated viral RNA, undergoing a conformational change that nucleates a signaling cascade through the mitochondrial adaptor MAVS, ultimately activating interferon regulatory factors. IRF7 is the master amplifier of type I interferon production, driving robust expression of IFN-alpha and IFN-beta, particularly in a feed-forward loop that escalates the antiviral response. Secreted type I interferons act in autocrine and paracrine fashion through their receptor to activate the JAK-STAT pathway, assembling the trimeric ISGF3 complex from STAT1, STAT2, and the DNA-binding partner IRF9, which binds interferon-stimulated response elements to induce hundreds of interferon-stimulated genes (ISGs). Type II interferon, IFN-gamma, signals predominantly through STAT1 homodimers to enhance macrophage activation and antigen presentation. The induced ISGs constitute the antiviral effector arsenal: ISG15 is a ubiquitin-like modifier that conjugates to viral and host proteins to restrict replication, IFITM3 blocks viral entry and fusion at endosomal membranes, and the oligoadenylate synthetase OAS3 senses double-stranded RNA and activates RNase L to degrade viral and cellular RNA. While essential for host defense, sustained or aberrant interferon signaling drives autoimmune interferonopathies and contributes to inflammatory disease. Dissecting sensing, signal transduction, and effector output requires reagents spanning each layer. This sampler pack brings together validated antibodies against RIG-I/DDX58, IRF7, IRF9, STAT1, STAT2, ISG15, IFITM3, and OAS3 for studying type I and type II interferon responses.

AnalyteAlternate Names
RIG-I / DDX58DDX58, RIG-I, Retinoic acid-inducible gene I, RIGI
IRF7Interferon regulatory factor 7
IRF9Interferon regulatory factor 9, ISGF3G, p48
STAT1Signal transducer and activator of transcription 1, ISGF-3
STAT2Signal transducer and activator of transcription 2, ISGF-3, P113
ISG15Interferon-stimulated gene 15, G1P2, UCRP, IP17
IFITM3Interferon induced transmembrane protein 3, 1-8U, DSPA2b
OAS32'-5'-oligoadenylate synthase 3, p100 OAS
SpecificationDetail
Pack Format8 antibodies, 20µL each (trial size)
StorageStore at -20°C upon receipt
Shelf Life12 months from date of receipt
ShippingGel pack
Scale-upEvery antibody is also available individually in a full 100µL size

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