Rat IL 1 alpha Recombinant Protein (RPPB0451)

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주문
SKU:
RPPB0451
Product type:
Recombinant Protein
Size:
20ug
Species:
Rat
Target:
IL 1 alpha
Synonyms:
Interleukin-1 alpha
Synonyms:
IL-1 alpha
Source:
Escherichia Coli
Uniprot:
P16598
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Description

Product Name:Rat IL 1 alpha Recombinant Protein
Product Code:RPPB0451
Size:20µg
Species:Rat
Target:IL 1 alpha
Synonyms:Interleukin-1 alpha, IL-1 alpha.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:IL 1 alpha protein solution (1mg/ml) containing PhosphateBuffered Saline (pH 7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrierprotein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Purity:Greaterthan 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSSAPHSFQ NNLRYKLIRI VKQEFIMNDS LNQNIYVDMD RIHLKAASLNDLQLEVKFDM YAYSSGGDDS KYPVTLKVSN TQLFVSAQGE DKPVLLKEIP ETPKLITGSE TDLIFFWEKINSKNYFTSAA FPELLIATKE QSQVHLARGL PSMIDFQIS
Biological Activity:The biological activity was Rat IL1 alpha was measured in a cell proliferation assay using D10.G4.1 mouse helper T cell. The ED50 for this effect is less or equal to 20 pg/ml.

IL-1 alpha is produced by activated macrophages, stimulates thymocyte proliferation by inducing il-2 release, b-cell maturation and proliferation, and fibroblast growth factor activity. IL1A proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.

IL 1 alpha Rat Recombinant produced in E.Coli is asingle, non-glycosylated polypeptide chain containing 179 amino acids (115-270 a.a)and having a molecular mass of 20.2kDa.IL 1 alpha is fused to a 23 amino acid His-tag atN-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
NCBI Summary:proinflammatory cytokine [RGD, Feb 2006]
UniProt Code:P16598
NCBI GenInfo Identifier:124301
NCBI Gene ID:24493
NCBI Accession:P16598.1
UniProt Secondary Accession:P16598,Q546R9,
UniProt Related Accession:P16598
Molecular Weight:30,856 Da
NCBI Full Name:Interleukin-1 alpha
NCBI Synonym Full Names:interleukin 1 alpha
NCBI Official Symbol:Il1a  
NCBI Official Synonym Symbols:IL-1 alpha  
NCBI Protein Information:interleukin-1 alpha
UniProt Protein Name:Interleukin-1 alpha
Protein Family:Interleukin
UniProt Gene Name:Il1a  
UniProt Entry Name:IL1A_RAT
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