Myelination / Oligodendrocyte Antibody Sampler Pack

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SKU:
ABSP041
Product Type:
Antibody
Size:
Antibody Sampler Pack
Size:
8 X 20μL
Reactivity:
Human
Mouse
Rat
Analytes:
MBP
MOG
PLP1
Olig2
Sox10
CNPase
MAG
NG2/CSPG4
  • Anti-Myelin Basic Protein Antibody (CAB1664)
  • Anti-Myelin oligodendrocyte glycoprotein [ARC0879] Monoclonal Antibody (CAB3992)
  • Anti-PLP1 Antibody (CAB14251)
  • Anti-Olig2 [ARC1032] Monoclonal Antibody (CAB4555)
  • Anti-SOX10 [ARC1767] Monoclonal Antibody (CAB8655)
  • Anti-CNPase Antibody (CAB1018)
  • Anti-MAG [ARC1691] Monoclonal Antibody (CAB9671)
  • Anti-CSPG4 Antibody -Knockout Validated (CAB3592)

Description

Myelination / Oligodendrocyte Antibody Sampler Pack

The Myelination / Oligodendrocyte Antibody Sampler Pack from Assay Genie brings together 8 rigorously validated antibodies spanning the key nodes of this pathway, supplied in a convenient 20µL trial size. It lets researchers screen an entire signalling axis in a single, cost-effective pack — validated for applications including ELISA, IF/ICC, IHC-P, WB — before committing to full-size vials. Each antibody is also available individually in a full 100µL size.

TargetAntibodyCat. No.HostReactivityApplicationsSize
MBPAnti-Myelin Basic Protein AntibodyCAB1664-20RabbitHuman, Mouse, RatWBIHC-PIF/ICCELISA20µL
MOGAnti-Myelin oligodendrocyte glycoprotein [ARC0879] Monoclonal AntibodyCAB3992-20RabbitMouse, RatWBIF/ICCELISA20µL
PLP1Anti-PLP1 AntibodyCAB14251-20RabbitHuman, Mouse, RatWBIF/ICCELISA20µL
Olig2Anti-Olig2 [ARC1032] Monoclonal AntibodyCAB4555-20RabbitMouse, RatWBELISA20µL
Sox10Anti-SOX10 [ARC1767] Monoclonal AntibodyCAB8655-20RabbitHuman, Mouse, RatWBIF/ICCELISA20µL
CNPaseAnti-CNPase AntibodyCAB1018-20RabbitHuman, Mouse, RatWBIF/ICCELISA20µL
MAGAnti-MAG [ARC1691] Monoclonal AntibodyCAB9671-20RabbitHuman, Mouse, RatWBELISA20µL
NG2/CSPG4Anti-CSPG4 Antibody -Knockout ValidatedCAB3592-20RabbitHuman, Mouse, RatWBIHC-PIF/ICCELISA20µL

Myelination is the process by which oligodendrocytes in the central nervous system wrap axons in multilayered lipid-rich sheaths that enable rapid saltatory conduction and provide metabolic and trophic support to axons. Disruption of myelin underlies demyelinating diseases such as multiple sclerosis and contributes to the axonal degeneration that follows. The oligodendrocyte lineage is specified and maintained by transcription factors, and two are central to this program. Sox10 is a master regulator expressed throughout the lineage that is required for oligodendrocyte differentiation and the expression of myelin genes, while Olig2 establishes oligodendrocyte identity from progenitors and persists in mature cells. Oligodendrocyte precursor cells, the dividing pool that generates new myelinating cells during development and remyelination, are identified by NG2/CSPG4, a surface proteoglycan that marks this population. As progenitors mature they express the structural constituents of compact myelin. MBP, myelin basic protein, is a major component that compacts the cytoplasmic surfaces of the myelin membrane, and PLP1, proteolipid protein, is the most abundant integral myelin protein that stabilizes the sheath. CNPase is an early and abundant oligodendrocyte enzyme enriched in non-compact myelin and used as a lineage and myelination marker. Two glycoproteins reside in specialized myelin domains: MAG, myelin-associated glycoprotein, mediates axon-glia interactions at the periaxonal membrane and signals to maintain axonal integrity, and MOG, myelin oligodendrocyte glycoprotein, sits on the outermost surface of myelin and is a prominent autoimmune target in demyelinating disease. Together these markers track the full trajectory from precursor specification to mature myelin assembly. This pack brings together validated antibodies against MBP, MOG, PLP1, Olig2, Sox10, CNPase, MAG, and NG2/CSPG4 to support investigation of myelination and oligodendrocyte biology.

AnalyteAlternate Names
MBPMyelin basic protein
MOGMyelin oligodendrocyte glycoprotein, BTN6, MOGIG2
PLP1Proteolipid protein 1, Lipophilin, PLP, Myelin proteolipid protein
Olig2Oligodendrocyte transcription factor 2, BHLHB1, BHLHE19
Sox10SRY-box transcription factor 10, SOX-10, DOM
CNPaseCNP, 2',3'-cyclic nucleotide 3' phosphodiesterase, CNP1
MAGMyelin-associated glycoprotein, GMA, Siglec-4a
NG2/CSPG4CSPG4, NG2, Chondroitin sulfate proteoglycan 4, MCSP, HMW-MAA
SpecificationDetail
Pack Format8 antibodies, 20µL each (trial size)
StorageStore at -20°C upon receipt
Shelf Life12 months from date of receipt
ShippingGel pack
Scale-upEvery antibody is also available individually in a full 100µL size

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