MSH2 Rabbit Monoclonal Antibody (CAB8740)

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SKU:
CAB8740
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling
Reactivity:
Human, Mouse, Rat
Synonyms:
FCC1, COCA1, HNPCC, LCFS2, MSH-2, hMSH2, HNPCC1, LYNCH1, MMRCS2, MSH2
Research Use:
Epigenetics and Nuclear Signaling

Description

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MSH2 Monoclonal Antibody (CAB8740)

The MSH2 Monoclonal Antibody (CAB8740) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced and validated for specificity in rabbit hosts, is highly reactive with human samples and is ideal for use in Western blot applications.MSH2 is a key component of the DNA mismatch repair system, responsible for recognizing and repairing errors in DNA replication. Mutations in MSH2 are associated with hereditary nonpolyposis colorectal cancer (HNPCC) and other forms of cancer, making it a crucial target for research in cancer biology and genetics.

This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.

Product Name:MSH2 Monoclonal Antibody
SKU:CAB8740
Size:20μL, 100μL
Reactivity:Human, Mouse, Rat
Clone Number:ARC1285
Conjugate:Unconjugated
Immunogen:Synthetic peptide. This information is considered to be commercially sensitive.
Sequence:MAVQ PKET LQLE SAAE VGFV RFFQ GMPE KPTT TVRL FDRG DFYT AHGE DALL AARE VFKT QGVI KYMG PAGA KNLQ SVVL SKMN FESF VKDL LLVR QYRV
Tested Applications:WB ELISA
Recommended Dilution:
WB1:500 - 1:2000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:FCC1, COCA1, HNPCC, LCFS2, MSH-2, hMSH2, HNPCC1, LYNCH1, MMRCS2, MSH2
Positive Sample:HeLa, 293T, A549, NIH/3T3, C6, Mouse testis
Cellular Localization:Nucleus.
Calculated MW:105kDa
Observed MW:105kDa

This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene.

Purification MethodAffinity purification
Gene ID4436
RRIDAB_2863598
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of various lysates using MSH2 Rabbit mAb (CAB8740) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 90s.

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