Mouse AHCY Recombinant Protein (RPPB1364)

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주문
SKU:
RPPB1364
Product type:
Recombinant Protein
Size:
20ug
Species:
Mouse
Target:
AHCY
Synonyms:
EC 3311
Synonyms:
SAHH
Synonyms:
AdoHcyase
Synonyms:
S-adenosyl-L-homocysteine hydrolase
Source:
Escherichia Coli
Uniprot:
P50247
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Description

Product Name:Mouse AHCY Recombinant Protein
Product Code:RPPB1364
Size:20µg
Species:Mouse
Target:AHCY
Synonyms:EC 3.3.1.1, SAHH, AdoHcyase, S-adenosyl-L-homocysteine hydrolase, Adenosylhomocysteinase.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:AHCY protein solution (0.25mg/ml) containing 20mM Tris-Hcl buffer (pH8.0) containing 40% glycerol 0.2M NaCl, 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage, it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMSDKLP YKVADIGLAA WGRKALDIAE NEMPGLMRMR EMYSASKPLK GARIAGCLHM TVETAVLIET LVALGAEVRW SSCNIFSTQD HAAAAIAKAG IPVFAWKGET DEEYLWCIEQ TLHFKDGPLN MILDDGGDLT NLIHTKYPQL LSGIRGISEE TTTGVHNLYK MMSNGILKVP AINVNDSVTK SKFDNLYGCR ESLIDGIKRA TDVMIAGKVA VVAGYGDVGK GCAQALRGFG ARVIITEIDP INALQAAMEG YEVTTMDEAC KEGNIFVTTT GCVDIILGRH FEQMKDDAIV CNIGHFDVEI DVKWLNENAV EKVNIKPQVD RYWLKNGRRI ILLAEGRLVN LGCAMGHPSF VMSNSFTNQV MAQIELWTHP DKYPVGVHFL PKKLDEAVAE AHLGKLNVKL TKLTEKQAQY LGMPINGPFK PDHYRY

AHCY is an enzyme that catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). AHCY controls the intracellular S-adenosylhomocysteine (SAH) concentration that is crucial for transmethylation reactions. AHCY deficiency causes hypermethioninemia.

AHCY Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 456 amino acids (1-432 a.a) and having a molecular mass of 50.2kDa.AHCY is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.
UniProt Code:P50247
NCBI GenInfo Identifier:21431841
NCBI Gene ID:11615
NCBI Accession:P50247.3
UniProt Secondary Accession:P50247,Q91WF1,
Molecular Weight:47,688 Da
NCBI Full Name:Adenosylhomocysteinase
NCBI Synonym Full Names:predicted gene 4737
NCBI Official Symbol:Gm4737  
NCBI Official Synonym Symbols:EG11615; AL024110  
NCBI Protein Information:predicted gene 4737
UniProt Protein Name:Adenosylhomocysteinase
UniProt Synonym Protein Names:CUBP; Liver copper-binding protein; S-adenosyl-L-homocysteine hydrolase
Protein Family:Adenosylhomocysteinase
UniProt Gene Name:Ahcy  
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