KIF2C/MCAK Rabbit Monoclonal Antibody (CAB9140)

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SKU:
CAB9140
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
Research Area:
Cell Cycle
Synonyms:
MCAK, CT139, KNSL6, KIF2C/MCAK
Research Use:
Cell Cycle

Description

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KIF2C/MCAK Monoclonal Antibody (CAB9140)

The KIF2C/MCAK Monoclonal Antibody (CAB9140) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, is highly specific for MCAK in human samples and has been validated for use in Western blotting and immunofluorescence applications. By targeting the MCAK protein, researchers can visualize and analyze its expression and localization in various cell types, providing insights into its role in cellular processes such as mitosis and cell motility.MCAK is known for its role in regulating microtubule dynamics, including depolymerization and severing, which are essential for proper chromosome segregation during cell division.

This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human samples.

Product Name:KIF2C/MCAK Monoclonal Antibody
SKU:CAB9140
Size:20μL, 100μL
Reactivity:Human
Clone Number:ARC1447
Conjugate:Unconjugated
Immunogen:Synthetic peptide. This information is considered to be commercially sensitive.
Sequence:MAMD SSLQ ARLF PGLA IKIQ RSNG LIHS ANVR TVNL EKSC VSVE WAEG GATK GKEI DFDD VAAI NPEL LQLL PLHP KDNL PLQE NVTI QKQK RRSV NSKI
Tested Applications:WB ELISA
Recommended Dilution:
WB1:500 - 1:1000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:MCAK, CT139, KNSL6, KIF2C/MCAK
Positive Sample:MCF7, PC-3, Jurkat
Cellular Localization:Chromosome, Cytoplasm, Nucleus, Centromere, Cytoskeleton, Kinetochore.
Calculated MW:81kDa
Observed MW:85kDa

This gene encodes a kinesin-like protein that functions as a microtubule-dependent molecular motor. The encoded protein can depolymerize microtubules at the plus end, thereby promoting mitotic chromosome segregation. Alternative splicing results in multiple transcript variants.

Purification MethodAffinity purification
Gene ID11004
RRIDAB_2863667
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of various lysates using KIF2C/KIF2C/MCAK Rabbit mAb (CAB9140) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 3min.

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