Human ZMAT3 Recombinant Protein (RPPB5181)
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주문- SKU:
- RPPB5181
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Human
- Target:
- ZMAT3
- Synonyms:
- Zinc Finger Matrin-Type 3
- Synonyms:
- Zinc Finger Protein WIG1
- Synonyms:
- P53-Activated Gene 608 Protein
- Synonyms:
- P53 Target Zinc Finger Protein
- Source:
- Escherichia Coli
- Uniprot:
- Q9HA38
Description
| Product Name: | Human ZMAT3 Recombinant Protein |
| Product Code: | RPPB5181 |
| Size: | 10µg |
| Species: | Human |
| Target: | ZMAT3 |
| Synonyms: | Zinc Finger Matrin-Type 3, Zinc Finger Protein WIG1, P53-Activated Gene 608 Protein, P53 Target Zinc Finger Protein, WIG1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The ZMAT3 solution contains 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 2mM DTT and 50% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMILLQHA VLPPPKQPSP SPPMSVATRS TGTLQLPPQK PFGQEASLPL AGEEELSKGG EQDCALEELC KPLYCKLCNV TLNSAQQAQA HYQGKNHGKK LRNYYAANSC PPPARMSNVV EPAATPVVPV PPQMGSFKPG GRVILATEND YCKLCDASFS SPAVAQAHYQ GKNHAKRLRL AEAQSNSFSE SSELGQRRAR KEGNEFKMMP NRRNMYTVQN NSAGPYFNPR SRQRIPRDLA MCVTPSGQFY CSMCNVGAGE EMEFRQHLES KQHKSKVSEQ RYRNEMENLG YV |
ZMAT3 is a protein with a nuclear localization signal and 3 zinc finger domains. The mRNA and the protein of this gene are upregulated by wildtype p53. When overexpressed, ZMAT3 can produce tumor cell growth, indicating that ZMAT3 takes part in the p53-dependent growth regulatory pathway. Alternative splicing of ZMAT3 produce two transcript variants encoding two isoforms differing in only one amino acid.
ZMAT3 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 312 amino acids (1-289) and having a molecular mass of 34.4kDa.ZMAT3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | ZMAT3: Acts as a bona fide target gene of p53/TP53. May play a role in the TP53-dependent growth regulatory pathway. May contribute to TP53-mediated apoptosis by regulation of TP53 expression and translocation to the nucleus and nucleolus. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Nucleolus Chromosomal Location of Human Ortholog: 3q26.32 Cellular Component: nucleolus Molecular Function:protein binding; zinc ion binding Biological Process: protein transport; apoptosis; positive regulation of apoptosis; regulation of growth; response to DNA damage stimulus |
| NCBI Summary: | This gene encodes a protein containing three zinc finger domains and a nuclear localization signal. The mRNA and the protein of this gene are upregulated by wildtype p53 and overexpression of this gene inhibits tumor cell growth, suggesting that this gene may have a role in the p53-dependent growth regulatory pathway. Alternative splicing of this gene results in two transcript variants encoding two isoforms differing in only one amino acid. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9HA38 |
| NCBI GenInfo Identifier: | 74734128 |
| NCBI Gene ID: | 64393 |
| NCBI Accession: | Q9HA38.1 |
| UniProt Secondary Accession: | Q9HA38,Q96A21, B3KVA6, D3DNR1, |
| UniProt Related Accession: | Q9HA38 |
| Molecular Weight: | 289 |
| NCBI Full Name: | Zinc finger matrin-type protein 3 |
| NCBI Synonym Full Names: | zinc finger, matrin-type 3 |
| NCBI Official Symbol: | ZMAT3 |
| NCBI Official Synonym Symbols: | WIG1; WIG-1; PAG608 |
| NCBI Protein Information: | zinc finger matrin-type protein 3; ZMAT3; WIG-1/PAG608 protein; zinc finger protein WIG1; zinc finger protein WIG-1; zinc finger, matrin type 3; p53 target zinc finger protein; p53-activated gene 608 protein |
| UniProt Protein Name: | Zinc finger matrin-type protein 3 |
| UniProt Synonym Protein Names: | Zinc finger protein WIG-1; p53-activated gene 608 protein |
| Protein Family: | Zinc finger matrin-type protein |
| UniProt Gene Name: | ZMAT3 |
| UniProt Entry Name: | ZMAT3_HUMAN |
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