Human WISP1 Recombinant Protein (RPPB1094)

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SKU:
RPPB1094
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
WISP1
Synonyms:
WNT1 Inducible Signaling Pathway Protein 1
Synonyms:
CCN Family Member 4
Synonyms:
CCN4
Synonyms:
Wnt-1 Inducible
Source:
HEK293 Cells
Uniprot:
O95388
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Description

Product Name:Human WISP1 Recombinant Protein
Product Code:RPPB1094
Size:10µg
Species:Human
Target:WISP1
Synonyms:WNT1 Inducible Signaling Pathway Protein 1, CCN Family Member 4, CCN4, Wnt-1 Inducible, Signaling Pathway Protein 1, WNT1 Induced Secreted Protein 1, Wnt-1-Induced Secreted Protein, CTC-458A3.8, WISP1tc, WISP1c, WISP1i, WISP-1, WISP1.
Source:HEK293 Cells
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:WISP1 protein was lyophilized from a 0.2µm filtered solution in PBS.
Solubility:It is recommended to add deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely.
Stability:Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.
Purity:Greater than 95.0% as determined by SDS-PAGE. 
Amino Acid Sequence:TALSPAPTTMDFTPAPLEDTSSRPQFCKWPCECPPSPPRCPLGVSLITDGCECCKMCAQQLGDNCTEAAICDPHRGLYCDYSGDRPRYAIGVCAQVVGVGCVLDGVRYNNGQSFQPNCKYNCTCIDGAVGCTPLCLRVRPPRLWCPHPRRVSIPGHCCEQWVCEDDAKRPRKTAPRDTGAFDAVGEVEAWHRNCIAYTSPWSPCSTSCGLGVSTRISNVNAQCWPEQESRLCNLRPCDVDIHTLIKAGKKCLAVYQPEASMNFTLAGCISTRSYQPKYCGVCMDNRCCIPYKSKTIDVSFQCPDGLGFSRQVLWINACFCNLSCRNPNDIFADLESYPDFSEIANHHHHHHHHHH

WISP1 is a part of a family of cysteine-rich, glycosylated signaling proteins that mediate varied developmental processes. WISP1 is a Downstream regulator in the Wnt/Frizzled-signaling pathway and is linked with cell survival.WISP1weakens p53-mediated apoptosis in response to DNA damage through activation of AKT kinase and up-regulates the anti-apoptotic Bcl-X(L) protein.

WISP1 Human Recombinant produced in Mouse myeloma cell line is a single, glycosylated polypeptide chain containing 355 amino acids (Thr23- Asn367), having a molecular mass of 39.3kDa and fused to a 10 aa His Tag.The WISP1 is purified by proprietary chromatographic techniques.

UniProt Protein Function:Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase. Up-regulates the anti-apoptotic Bcl-X(L) protein. Adheres to skin and melanoma fibroblasts. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan.
NCBI Summary:This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2011]
UniProt Code:O95388
NCBI GenInfo Identifier:34098393
NCBI Gene ID:8840
NCBI Accession:O95388.1
UniProt Secondary Accession:O95388,Q5JBS6, Q5JBS7, Q5JBS8, Q9HCS3, A8KAG6, E7EMM5
UniProt Related Accession:O95388
Molecular Weight:21,550 Da
NCBI Full Name:WNT1-inducible-signaling pathway protein 1
NCBI Synonym Full Names:WNT1 inducible signaling pathway protein 1
NCBI Official Symbol:WISP1  
NCBI Official Synonym Symbols:CCN4; WISP1c; WISP1i; WISP1tc  
NCBI Protein Information:WNT1-inducible-signaling pathway protein 1
UniProt Protein Name:WNT1-inducible-signaling pathway protein 1
UniProt Synonym Protein Names:CCN family member 4; Wnt-1-induced secreted protein
Protein Family:WNT1-inducible-signaling pathway protein
UniProt Gene Name:WISP1  
UniProt Entry Name:WISP1_HUMAN
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