Human UTP23 Recombinant Protein (RPPB5098)

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SKU:
RPPB5098
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
UTP23
Synonyms:
UTP23 Small Subunit (SSU) Processome Component
Synonyms:
Homolog (Yeast)
Synonyms:
Chromosome 8 Open Reading Frame 53
Synonyms:
RRNA-Processing Protein UTP23 Homolog
Source:
Escherichia Coli
Uniprot:
Q9BRU9
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Description

Product Name:Human UTP23 Recombinant Protein
Product Code:RPPB5098
Size:20µg
Species:Human
Target:UTP23
Synonyms:UTP23 Small Subunit (SSU) Processome Component, Homolog (Yeast), Chromosome 8 Open Reading Frame 53, RRNA-Processing Protein UTP23 Homolog, MGC14595, C8orf53.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The UTP23 solution contains 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 1mM DTT and 20% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMKITRQK HAKKHLGFFR NNFGVREPYQ ILLDGTFCQA ALRGRIQLRE QLPRYLMGET QLCTTRCVLK ELETLGKDLY GAKLIAQKCQ VRNCPHFKNA VSGSECLLSM VEEGNPHHYF VATQDQNLSV KVKKKPGVPL MFIIQNTMVL DKPSPKTIAF VKAVESGQLV SVHEKESIKH LKEEQGLVKN TEQSRRKKRK KISGPNPLSC LKKKKKAPDT QSSASEKKRK RKRIRNRSNP KVLSEKQNAE GE

rRNA-processing protein UTP23 homolog (UTP23) is a small subunit (SSU) processome component. The SSU processome is a complex involved in ribosome biogenesis and essential for pre-18S rRNA maturation. UTP23 is vital for the first 3 cleavage steps in 18S rRNA maturation. Furthermore, single-point mutations in the conserved putative active site of Utp24 but not Utp23 annul its function in ribosome biogenesis.

UTP23 Human Recombinant produced in E. coli is a single polypeptide chain containing 272 amino acids (1-249) and having a molecular mass of 30.8 kDa.UTP23 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:UTP23: Involved in rRNA-processing and ribosome biogenesis. Belongs to the UTP23/FCF1 family. UTP23 subfamily. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Nucleolus; RNA processingChromosomal Location of Human Ortholog: 8q24.11Cellular Component: small subunit processome; nucleolusBiological Process: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
UniProt Protein Details:
NCBI Summary:
UniProt Code:Q9BRU9
NCBI GenInfo Identifier:18490658
NCBI Gene ID:84294
NCBI Accession:AAH22441.1
UniProt Secondary Accession:Q9BRU9,Q96NJ8, B2RE25
UniProt Related Accession:Q9BRU9
Molecular Weight:16,680 Da
NCBI Full Name:UTP23, small subunit (SSU) processome component, homolog (yeast)
NCBI Synonym Full Names:UTP23, small subunit (SSU) processome component, homolog (yeast)
NCBI Official Symbol:UTP23  
NCBI Official Synonym Symbols:C8orf53  
NCBI Protein Information:rRNA-processing protein UTP23 homolog
UniProt Protein Name:rRNA-processing protein UTP23 homolog
UniProt Synonym Protein Names:
Protein Family:rRNA-processing protein
UniProt Gene Name:UTP23  
UniProt Entry Name:UTP23_HUMAN
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