Description
| Product Name: | Human Uteroglobin/SCGB1A1 Recombinant Protein (His Tag) |
| Product Code: | RPES5976 |
| Size: | 20µg |
| Species: | Human |
| Expression Host: | HEK293 Cells |
| Synonyms: | Uteroglobin, Clara cell phospholipid-binding protein, CCPBP, Clara cells 10 kDa secretory protein, CC10, Secretoglobin family 1A member 1, Urinary protein 1, UP-1, UP1, Urine protein 1, SCGB1A1, CCSP, UGB |
| Mol Mass: | 9.9 kDa |
| AP Mol Mass: | 10 kDa |
| Tag: | C-His |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin Level: | Please contact us for more information. |
| Bio Activity: | Testing in progress |
| Sequence: | Glu22-Asn91 |
| Accession: | P11684 |
| Storage: | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation: | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution: | Please refer to the printed manual for detailed information. |
| Background: | Uteroglobin is a small; non-glycosylated secreted protein of the secretoglobin superfamily. It is produced by the non-ciliated; non-mucous secretory cells that predominate in lung bronchioles (Clara cells); and other non-ciliated epithelia that communicate with the external environment. Expression is induced by steroid hormones such as estrogen; and enhanced by the non-steroid hormone prolactin. Human Uteroglobin cDNA encodes a 21 amino acid (aa) signal sequence and a 70 aa mature protein. The mature protein forms a disulfide-linked head-to-tail homodimer of 16 kDa. This homodimer is thought to form a binding pocket that binds hydrophobic ligands such as phospholipids; progesterone and retinols. Binding of fibronectin to Uteroglobin in the kidney is thought to protect against nephropathy; while binding of the lipocalin-1 receptor has been reported to suppress cancer cell motility and invasion. |
