Human SETD7 Recombinant Protein (RPPB2272)

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주문
SKU:
RPPB2272
Product type:
Recombinant Protein
Size:
50ug
Species:
Human
Target:
SETD7
Synonyms:
Histone-lysine N-methyltransferase
Synonyms:
H3 lysine-4 specific SET7
Synonyms:
EC 21143
Synonyms:
Histone H3-K4 methyltransferase
Source:
Escherichia Coli
Uniprot:
Q8WTS6
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Description

Product Name:Human SETD7 Recombinant Protein
Product Code:RPPB2272
Size:50µg
Species:Human
Target:SETD7
Synonyms:Histone-lysine N-methyltransferase, H3 lysine-4 specific SET7, EC 2.1.1.43, Histone H3-K4 methyltransferase, H3-K4-HMTase, SET domain-containing protein 7, Set9, SET7/9, SETD7.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The protein containing 50mM Tris-HCl buffer (pH7.5), 0.2M NaCl, 5mM DTT and 20% glycerol.
Stability:Store at 4°C if entire vial will be used within 1-2 weeks. Store, frozen at -20°C for longer periods of time.Please prevent freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MDSDDEMVEE AVEGHLDDDG LPHGFCTVTY SSTDRFEGNF VHGEKNGRGK FFFFDGSTLE GYYVDDALQG QGVYTYEDGG VLQGTYVDGE LNGPAQEYDT DGRLIFKGQY KDNIRHGVCW IYYPDGGSLV GEVNEDGEMT GEKIAYVYPD ERTALYGKFI DGEMIEGKLA TLMSTEEGRP HFELMPGNSV YHFDKSTSSC ISTNALLPDP YESERVYVAE SLISSAGEGL FSKVAVGPNT VMSFYNGVRI THQEVDSRDW ALNGNTLSLD EETVIDVPEP YNHVSKYCAS LGHKANHSFT PNCIYDMFVH PRFGPIKCIR TLRAVEADEE LTVAYGYDHS PPGKSGPEAP EWYQVELKAF QATQQK

Set 7/9 is a histone methyltransferase (HMTase) that transfers methyl groups to Lys4 of histone H3, in complex with S-adenosyl-L-methionine (AdoMet). The methylation of lysine residues of histones plays a critical role in the regulation of chromatin structure and gene expression. Acetylation, phosphorylation and methylation of the amino-terminal tails of histone are thought to be involved in the regulation of chromatin structure and function. The enzymes identified in the methylation of specific lysine residue on histones belong to the SET family with just one exception. Set7/9, unlike most other SET proteins, is exclusively a mono-methylase.

SETD7 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 366 amino acids & having a molecular mass of 40.7 kDa. The SETD7 purified by proprietary chromatographic techniques.

UniProt Protein Function:Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.
UniProt Code:Q8WTS6
NCBI GenInfo Identifier:25091217
NCBI Gene ID:80854
NCBI Accession:Q8WTS6.1
UniProt Secondary Accession:Q8WTS6,Q0VAH3, Q4W5A9, Q9C0E6, B5WWL3,
UniProt Related Accession:Q8WTS6
Molecular Weight:40,721 Da
NCBI Full Name:Histone-lysine N-methyltransferase SETD7
NCBI Synonym Full Names:SET domain containing lysine methyltransferase 7
NCBI Official Symbol:SETD7  
NCBI Official Synonym Symbols:KMT7; SET7; SET9; SET7/9  
NCBI Protein Information:histone-lysine N-methyltransferase SETD7
UniProt Protein Name:Histone-lysine N-methyltransferase SETD7
UniProt Synonym Protein Names:Histone H3-K4 methyltransferase SETD7; H3-K4-HMTase SETD7; Lysine N-methyltransferase 7; SET domain-containing protein 7; SET7/9
Protein Family:Histone-lysine N-methyltransferase
UniProt Gene Name:SETD7  
UniProt Entry Name:SETD7_HUMAN
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