Human SERTAD1 Recombinant Protein (RPPB4650)

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SKU:
RPPB4650
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
SERTAD1
Synonyms:
SERTA domain-containing protein 1
Synonyms:
CDK4-binding protein p34SEI1
Synonyms:
SEI-1
Synonyms:
Transcriptional regulator interacting with the PHD-bromodomain 1
Source:
Escherichia Coli
Uniprot:
Q9UHV2
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Description

Product Name:Human SERTAD1 Recombinant Protein
Product Code:RPPB4650
Size:10µg
Species:Human
Target:SERTAD1
Synonyms:SERTA domain-containing protein 1, CDK4-binding protein p34SEI1, SEI-1, Transcriptional regulator interacting with the PHD-bromodomain 1, TRIP-Br1, SERTAD1, SEI1.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:SERTAD1 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 10% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMLSKGL KRKREEEEEK EPLAVDSWWL DPGHTAVAQA PPAVASSSLF DLSVLKLHHS LQQSEPDLRH LVLVVNTLRR IQASMAPAAA LPPVPSPPAA PSVADNLLAS SDAALSASMA SLLEDLSHIE GLSQAPQPLA DEGPPGRSIG GAAPSLGALD LLGPATGCLL DDGLEGLFED IDTSMYDNEL WAPASEGLKP GPEDGPGKEE APELDEAELD YLMDVLVGTQ ALERPPGPGR

SERTA domain-containing protein (SERTAD1) functions with E2F-responsive promoters to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. SERTAD1 stimulates E2F-1/DP-1 transcriptional activity. SERTAD1 reduces the activity of cyclin D1/CDK4 resistant to the inhibitory effects of p16(INK4a). In addition, SERTAD1 interacts with the PHD-bromodomain of TIF1, TRIM28/TIF1B and p300/CBP. Furthermore, SERTAD1 binds to DP1 and interacts with CDK4.

SERTAD1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 260 amino acids (1-236 a.a) and having a molecular mass of 27.3kDa (Molecular weight on SDS-PAGE will appear higher).SERTAD1 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:SERTAD1: Acts at E2F-responsive promoters to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. Stimulates E2F-1/DP-1 transcriptional activity. Renders the activity of cyclin D1/CDK4 resistant to the inhibitory effects of p16(INK4a).
UniProt Protein Details:

Protein type:Cell cycle regulation; Transcription regulation

Chromosomal Location of Human Ortholog: 19q13.1-q13.2

Molecular Function:protein binding

Biological Process: transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; positive regulation of cell proliferation; regulation of cyclin-dependent protein kinase activity

UniProt Code:Q9UHV2
NCBI GenInfo Identifier:153792060
NCBI Gene ID:29950
NCBI Accession:NP_037508.2
UniProt Secondary Accession:Q9UHV2,Q9BUE7,
UniProt Related Accession:Q9UHV2
Molecular Weight:24,704 Da
NCBI Full Name:SERTA domain-containing protein 1
NCBI Synonym Full Names:SERTA domain containing 1
NCBI Official Symbol:SERTAD1  
NCBI Official Synonym Symbols:SEI1; TRIP-Br1  
NCBI Protein Information:SERTA domain-containing protein 1; CDK4-binding protein p34SEI; CDK4-binding protein p34SEI1; SEI-1; transcriptional regulator interacting with the PHD-bromodomain 1
UniProt Protein Name:SERTA domain-containing protein 1
UniProt Synonym Protein Names:CDK4-binding protein p34SEI1; SEI-1; Transcriptional regulator interacting with the PHD-bromodomain 1; TRIP-Br1
UniProt Gene Name:SERTAD1  
UniProt Entry Name:SRTD1_HUMAN
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