Human RAB31 Recombinant Protein (RPPB4359)

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SKU:
RPPB4359
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
RAB31
Synonyms:
Ras-related protein Rab-31
Synonyms:
Ras-related protein Rab-22B
Synonyms:
RAB31
Synonyms:
RAB22B
Source:
Escherichia Coli
Uniprot:
Q13636
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Description

Product Name:Human RAB31 Recombinant Protein
Product Code:RPPB4359
Size:20µg
Species:Human
Target:RAB31
Synonyms:Ras-related protein Rab-31, Ras-related protein Rab-22B, RAB31, RAB22B.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:RAB31 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl and 30% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMMA IRELKVCLLG DTGVGKSSIV CRFVQDHFDH NISPTIGASF MTKTVPCGNE LHKFLIWDTA GQERFHSLAP MYYRGSAAAV IVYDITKQDS FYTLKKWVKE LKEHGPENIV MAIAGNKCDL SDIREVPLKD AKEYAESIGA IVVETSAKNA INIEELFQGI SRQIPPLDPH ENGNNGTIKV EKPTMQASRR CC

RAB31 Member RAS Oncogene Family (RAB31) is a 194 amino lipid-anchored protein which localizes to the cytoplasmic side of the cell membrane and is a member of the Ras related GTPase superfamily. RAB31 is expressed at high levels in the lung, brain and heart. RAB31 functions in a similar mode to other Rab proteins, namely playing a part in protein transport. Small GTP-binding proteins of the RAB family, for example RAB31, play critical roles in vesicle and granule targeting. RAB31 gas the highest expression in the placenta and brain with lower levels in the heart and lung. However, RAB31 is not detected in liver, skeletal muscle, kidney or pancreas.

RAB31 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 232 amino acids (1-195 a.a) and having a molecular mass of 25.9kDa.RAB31 is fused to a 37 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:RAB31: Belongs to the small GTPase superfamily. Rab family
UniProt Protein Details:

Protein type:G protein, monomeric; G protein; G protein, monomeric, Rab

Chromosomal Location of Human Ortholog: 18p11.3

Cellular Component: phagocytic vesicle membrane; late endosome; early endosome; trans-Golgi network membrane; phagocytic vesicle

Molecular Function:GTPase activity; GDP binding; GTP binding

Biological Process: regulated secretory pathway; cellular response to insulin stimulus; receptor internalization; Golgi to plasma membrane protein transport; Rab protein signal transduction

NCBI Summary:Small GTP-binding proteins of the RAB family, such as RAB31, play essential roles in vesicle and granule targeting (Bao et al., 2002 [PubMed 11784320]).[supplied by OMIM, Jul 2009]
UniProt Code:Q13636
NCBI GenInfo Identifier:2500069
NCBI Gene ID:11031
NCBI Accession:Q13636.1
UniProt Secondary Accession:Q13636,Q15770, Q9HC00, B2RBT7,
UniProt Related Accession:Q13636
Molecular Weight:194
NCBI Full Name:Ras-related protein Rab-31
NCBI Synonym Full Names:RAB31, member RAS oncogene family
NCBI Official Symbol:RAB31  
NCBI Official Synonym Symbols:Rab22B  
NCBI Protein Information:ras-related protein Rab-31; ras-related protein Rab-22B
UniProt Protein Name:Ras-related protein Rab-31
UniProt Synonym Protein Names:Ras-related protein Rab-22B
Protein Family:Ras-related protein
UniProt Gene Name:RAB31  
UniProt Entry Name:RAB31_HUMAN
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