Human PNOC Recombinant Protein (RPPB4266)

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SKU:
RPPB4266
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
PNOC
Synonyms:
Prepronociceptin
Synonyms:
Nocistatin
Synonyms:
OFQ
Synonyms:
Pre-Pro-N/OFQ
Source:
Escherichia Coli
Uniprot:
Q13519
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Description

Product Name:Human PNOC Recombinant Protein
Product Code:RPPB4266
Size:20µg
Species:Human
Target:PNOC
Synonyms:Prepronociceptin, Nocistatin, OFQ, Pre-Pro-N/OFQ,Pronociceptin, Orphanin FQ, Nociceptin, PpN/OFQ, N/OFQ, PPNOC.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:PNOC protein solution (1mg/ml) containing 20mM Tris-HClbuffer (pH 8.0), 0.4M urea and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSSCQRDCL TCQEKLHPAL DSFDLEVCIL ECEEKVFPSP LWTPCTKVMA RSSWQLSPAA PEHVAAALYQ PRASEMQHLR RMPRVRSLFQ EQEEPEPGME EAGEMEQKQL QKRFGGFTGA RKSARKLANQ KRFSEFMRQY LVLSMQSSQR RRTLHQNGNV

Prepronociceptin (PNOC) is the ligand of the opioid receptor-like receptor (OPRL1). PNOC functions as a transmitter in the brain by modulating nociceptive and locomotor behavior. The PNOC protein may also be involved in neuronal differentiation and development.

PNOC Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 180 amino acids (20-176) and having a molecular mass of 20.6kDa. PNOC is fused to a 23 amino acid His-tag at N-terminus.

UniProt Protein Function:PNOC: Nociceptin is the ligand of the opioid receptor-like receptor (OPRL1). It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development. Belongs to the opioid neuropeptide precursor family.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 8p21

Cellular Component: extracellular region

Molecular Function:neuropeptide hormone activity; protein binding; opioid peptide activity

Biological Process: synaptic transmission; neuropeptide signaling pathway; sensory perception; signal transduction

NCBI Summary:This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include nociceptin, nocistatin, and orphanin FQ2 (OFQ2). Nociceptin, also known as orphanin FQ, is a 17-amino acid neuropeptide that binds to the nociceptin receptor to induce increased pain sensitivity, and may additionally regulate body temperature, learning and memory, and hunger. Another product of the encoded preproprotein, nocistatin, may inhibit the effects of nociceptin. [provided by RefSeq, Jul 2015]
UniProt Code:Q13519
NCBI GenInfo Identifier:2494348
NCBI Gene ID:5368
NCBI Accession:Q13519.1
UniProt Related Accession:Q13519
Molecular Weight:13kDa; 20kDa
NCBI Full Name:Prepronociceptin
NCBI Synonym Full Names:prepronociceptin
NCBI Official Symbol:PNOC  
NCBI Official Synonym Symbols:NOP; OFQ; N/OFQ; PPNOC; ppN/OFQ  
NCBI Protein Information:prepronociceptin
UniProt Protein Name:Prepronociceptin
UniProt Synonym Protein Names:Orphanin FQ; PPNOC
Protein Family:Prepronociceptin
UniProt Gene Name:PNOC  
UniProt Entry Name:PNOC_HUMAN
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