Human PGM1 Recombinant Protein (RPPB2102)

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SKU:
RPPB2102
Product type:
Recombinant Protein
Size:
25ug
Species:
Human
Target:
PGM1
Synonyms:
PGM1
Synonyms:
Phosphoglucomutase 1
Synonyms:
Glucose Phosphomutase 1
Synonyms:
EC 5422
Source:
Escherichia Coli
Uniprot:
P36871
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Description

Product Name:Human PGM1 Recombinant Protein
Product Code:RPPB2102
Size:25µg
Species:Human
Target:PGM1
Synonyms:PGM1, Phosphoglucomutase 1, Glucose Phosphomutase 1, EC 5.4.2.2, PGM 1, CDG1T, GSD14, Phosphoglucomutase-1, EC 5.4.2.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear colorless solution.
Formulation:PGM1 protein solution (1mg/ml) containing Phosphate Buffered Saline (pH 7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMVKIVTV KTQAYQDQKP GTSGLRKRVK VFQSSANYAE NFIQSIISTV EPAQRQEATL VVGGDGRFYM KEAIQLIARI AAANGIGRLV IGQNGILSTP AVSCIIRKIK AIGGIILTAS HNPGGPNGDF GIKFNISNGG PAPEAITDKI FQISKTIEEY AVCPDLKVDL GVLGKQQFDL ENKFKPFTVE IVDSVEAYAT MLRSIFDFSA LKELLSGPNR LKIRIDAMHG VVGPYVKKIL CEELGAPANS AVNCVPLEDF GGHHPDPNLT YAADLVETMK SGEHDFGAAF DGDGDRNMIL GKHGFFVNPS DSVAVIAANI FSIPYFQQTG VRGFARSMPT SGALDRVASA TKIALYETPT GWKFFGNLMD ASKLSLCGEE SFGTGSDHIR EKDGLWAVLA WLSILATRKQ SVEDILKDHW QKYGRNFFTR YDYEEVEAEG ANKMMKDLEA LMFDRSFVGK QFSANDKVYT VEKADNFEYS DPVDGSISRN QGLRLIFTDG SRIVFRLSGT GSAGATIRLY IDSYEKDVAK INQDPQVMLA PLISIALKVS QLQERTGRTA PTVIT

Phosphoglucomutase-1 also known as PGM1 is a member of the phosphohexose mutase family. There are more than a few PGM isozymes, which catalyzethe transfer of phosphate between the 1&6 positionsof glucose. In nearly all cell types, PGM1 isozymes predominate, representing around90% of total PGM activity.  It has been foundthat defects in PGM1 are the cause of glycogen storage disease type 14.

PGM1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 585 amino acids (1-562 a.a) and having a molecular mass of 63.8kDa.PGM1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:This enzyme participates in both the breakdown and synthesis of glucose.
NCBI Summary:The protein encoded by this gene is an isozyme of phosphoglucomutase (PGM) and belongs to the phosphohexose mutase family. There are several PGM isozymes, which are encoded by different genes and catalyze the transfer of phosphate between the 1 and 6 positions of glucose. In most cell types, this PGM isozyme is predominant, representing about 90% of total PGM activity. In red cells, PGM2 is a major isozyme. This gene is highly polymorphic. Mutations in this gene cause glycogen storage disease type 14. Alternativley spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Mar 2010]
UniProt Code:P36871
NCBI GenInfo Identifier:585670
NCBI Gene ID:5236
NCBI Accession:P36871.3
UniProt Secondary Accession:P36871,Q16105, Q16106, Q5BKZ9, Q6NW22, Q86U74, Q96J40 Q9NTY4, B2R5N9, B4DPV0,
UniProt Related Accession:P36871
Molecular Weight:40,283 Da
NCBI Full Name:Phosphoglucomutase-1
NCBI Synonym Full Names:phosphoglucomutase 1
NCBI Official Symbol:PGM1  
NCBI Official Synonym Symbols:CDG1T; GSD14  
NCBI Protein Information:phosphoglucomutase-1
UniProt Protein Name:Phosphoglucomutase-1
UniProt Synonym Protein Names:Glucose phosphomutase 1
Protein Family:Phosphoglucomutase
UniProt Gene Name:PGM1  
UniProt Entry Name:PGM1_HUMAN
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