Human PEF1 Recombinant Protein (RPPB4223)

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SKU:
RPPB4223
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
PEF1
Synonyms:
Peflin
Synonyms:
PEF protein with a long N-terminal hydrophobic domain
Synonyms:
Penta-EF hand domain-containing protein 1
Synonyms:
PEF1
Source:
Escherichia Coli
Uniprot:
Q9UBV8
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Description

Product Name:Human PEF1 Recombinant Protein
Product Code:RPPB4223
Size:10µg
Species:Human
Target:PEF1
Synonyms:Peflin, PEF protein with a long N-terminal hydrophobic domain, Penta-EF hand domain-containing protein 1, PEF1, ABP32, PEF1A.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The PEF1 solution (0.25 mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 50% glycerol and 0.2M NaCl.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMASY PYRQGCPGAA GQAPGAPPGSYYPGPPNSGG QYGSGLPPGG GYGGPAPGGP YGPPAGGGPY GHPNPGMFPS GTPGGPYGGAAPGGPYGQPP PSSYGAQQPG LYGQGGAPPN VDPEAYSWFQ SVDSDHSGYI SMKELKQALVNCNWSSFNDE TCLMMINMFD KTKSGRIDVY GFSALWKFIQ QWKNLFQQYD RDRSGSISYTELQQALSQMG YNLSPQFTQL LVSRYCPRSA NPAMQLDRFI QVCTQLQVLT EAFREKDTAVQGNIRLSFED FVTMTASRML

Penta-EF-hand domain containing 1 (PEF1) is a member of the penta-EF-hand protein family, which shares similarities to the apoptosis linked gene ALG-2. PEF1 forms heterodimers with PDCD6/ALG2 and dissociates from PDCD6/ALG2 in the presence of Ca (2+). Furthermore, PEF1 proteins bind calcium and participate in a various calcium-dependent processes in vertebrates.

PEF1 Human Recombinant fused with a 36 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 320 amino acids (1-284 a.a.) and having a molecular mass of 34.5kDa. The PEF1 is purified by proprietary chromatographic techniques.

UniProt Protein Function:PEF1: Heterodimer; heterodimerizes with PDCD6/ALG2. Dissociates from PDCD6/ALG2 in presence of Ca(2+).
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 1p34

Cellular Component: membrane; cytoplasm

Molecular Function:protein dimerization activity; protein binding; protein heterodimerization activity; calcium-dependent cysteine-type endopeptidase activity; calcium ion binding

Biological Process: proteolysis; response to calcium ion

NCBI Summary:This gene encodes a calcium-binding protein belonging to the penta-EF-hand protein family. The encoded protein has been shown to form a heterodimer with the programmed cell death 6 gene product and may modulate its function in Ca(2+) signaling. Alternative splicing results in multiple transcript variants and a pseudogene has been identified on chromosome 1.[provided by RefSeq, May 2010]
UniProt Code:Q9UBV8
NCBI GenInfo Identifier:74761895
NCBI Gene ID:553115
NCBI Accession:Q9UBV8.1
UniProt Related Accession:Q9UBV8
Molecular Weight:30,381 Da
NCBI Full Name:Peflin
NCBI Synonym Full Names:penta-EF-hand domain containing 1
NCBI Official Symbol:PEF1  
NCBI Official Synonym Symbols:ABP32; PEF1A  
NCBI Protein Information:peflin; PEF protein with a long N-terminal hydrophobic domain; penta-EF hand domain containing 1
UniProt Protein Name:Peflin
UniProt Synonym Protein Names:PEF protein with a long N-terminal hydrophobic domain; Penta-EF hand domain-containing protein 1
Protein Family:Peflin
UniProt Gene Name:PEF1  
UniProt Entry Name:PEF1_HUMAN
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