Human ORM1 Recombinant Protein (RPPB4347)

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SKU:
RPPB4347
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
ORM1
Synonyms:
Orosomucoid 1
Synonyms:
ORM
Synonyms:
AGP1
Synonyms:
OMD 1
Source:
Human pooled serum
Uniprot:
P02763
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Description

Product Name:Human ORM1 Recombinant Protein
Product Code:RPPB4347
Size:10µg
Species:Human
Target:ORM1
Synonyms:Orosomucoid 1, ORM, AGP1, OMD 1, AGP-A, alpha-1-acid glycoprotein 1, ORM1.
Source:Human pooled serum
Physical Appearance:Filtered White lyophilized (freeze-dried) powder.
Formulation:ORM1 protein filtered (0.4µm) and lyophilized in 0.5 mg/ml in 20mM TRIS and 50mM NaCl, pH 7.5.
Solubility:It is recommended to add deionized water to prepare a working stock solution of approximately 0.5 mg/ml and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
Stability:Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:QIPLCANLVP VPITNATLDQ ITGKWFYIAS AFRNEEYNKS VQEIQATFFY FTPNKTEDTI FLREYQTRQD QCIYNTTYLN VQRENGTISR YVGGQEHFAH LLILRDTKTY MLAFDVNDEK NWGLSVYADK PETTKEQLGE FYEALDCLRI PKSDVVYTDW KKDKCEPLEK QHEKERKQEE GES

The acute phase plasma protein ORM1 synthesized by the liver mediates the interaction between blood cells and endothelial cells. In addition, together with haptoglobin and C reactive protein, ORM1 regulates the extravasation of the cells through infection and inflammation. Expression of ORM1 is induced by acute-phase stimulatory mediators such as bacterial lipopolysaccharides.

The Human Orosomucoid 1 produced from Human pooled serum has a molecular mass of 21.56kDa (calculated without glycosylation) containing 183 amino acid residues.

UniProt Protein Function:ORM1: Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction. Belongs to the calycin superfamily. Lipocalin family.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 9q32

Cellular Component: extracellular space; extracellular region

Molecular Function:protein binding

Biological Process: regulation of immune system process; transport; acute-phase response; inflammatory response

NCBI Summary:This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression. [provided by RefSeq, Jul 2008]
UniProt Code:P02763
NCBI GenInfo Identifier:112877
NCBI Gene ID:5004
NCBI Accession:P02763.1
UniProt Secondary Accession:P02763,Q60590, P02764,
UniProt Related Accession:P02763
Molecular Weight:
NCBI Full Name:Alpha-1-acid glycoprotein 1
NCBI Synonym Full Names:orosomucoid 1
NCBI Official Symbol:ORM1  
NCBI Official Synonym Symbols:ORM; AGP1; AGP-A; HEL-S-153w  
NCBI Protein Information:alpha-1-acid glycoprotein 1
UniProt Protein Name:Alpha-1-acid glycoprotein 1
UniProt Synonym Protein Names:Orosomucoid-1; OMD 1
Protein Family:ORM1-like protein
UniProt Gene Name:ORM1  
UniProt Entry Name:A1AG1_HUMAN
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