Human NDUFAF1 Recombinant Protein (RPPB2006)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- RPPB2006
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Human
- Target:
- NDUFAF1
- Synonyms:
- Complex I intermediate-associated protein 30
- Synonyms:
- mitochondrial
- Synonyms:
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 1
- Synonyms:
- NDUFAF1
- Source:
- Escherichia Coli
- Uniprot:
- Q9Y375
Frequently bought together:
Description
| Product Name: | Human NDUFAF1 Recombinant Protein |
| Product Code: | RPPB2006 |
| Size: | 20µg |
| Species: | Human |
| Target: | NDUFAF1 |
| Synonyms: | Complex I intermediate-associated protein 30, mitochondrial, NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 1, NDUFAF1, CIA30, CGI-65, CGI65. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The NDUFAF1 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSYPFLGIR FAEYSSSLQK PVASPGKASS QRKTEGDLQG DHQKEVALDI TSSEEKPDVS FDKAIRDEAI YHFRLLKDEI VDHWRGPEGH PLHEVLLEQA KVVWQFRGKE DLDKWTVTSD KTIGGRSEVF LKMGKNNQSA LLYGTLSSEA PQDGESTRSG YCAMISRIPR GAFERKMSYD WSQFNTLYLR VRGDGRPWMV NIKEDTDFFQ RTNQMYSYFM FTRGGPYWQE VKIPFSKFFF SNRGRIRDVQ HELPLDKISS IGFTLADKVD GPFFLEIDFI GVFTDPAHTE EFAYENSPEL NPRLFK |
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 (NDUFAF4) is involved in the compilation of mitochondrial NADH: ubiquinone oxidoreductase complex (complex I). In addition, NDUFAF4 is involved in cell proliferation and survival of hormone-dependent tumor cells. NDUFAF4 may also be a regulator of breast tumor cell invasion. NDUFAF4 gene mutations cause the mitochondrial complex I deficiency.
NDUFAF1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 326 amino acids (25-327) and having a molecular mass of 37kDa.NDUFAF1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | NDUFAF1: Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Belongs to the CIA30 family. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 15q11.2-q21.3 Cellular Component: cytoplasm; mitochondrial inner membrane Molecular Function:protein binding Biological Process: mitochondrial respiratory chain complex I assembly Disease: Mitochondrial Complex I Deficiency |
| NCBI Summary: | This gene encodes a complex I assembly factor protein. Complex I (NADH-ubiquinone oxidoreductase) catalyzes the transfer of electrons from NADH to ubiquinone (coenzyme Q) in the first step of the mitochondrial respiratory chain, resulting in the translocation of protons across the inner mitochondrial membrane. The encoded protein is required for assembly of complex I, and mutations in this gene are a cause of mitochondrial complex I deficiency. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 19. [provided by RefSeq, Dec 2011] |
| UniProt Code: | Q9Y375 |
| NCBI GenInfo Identifier: | 21542405 |
| NCBI Gene ID: | 51103 |
| NCBI Accession: | Q9Y375.2 |
| UniProt Secondary Accession: | Q9Y375,Q9BVZ5, |
| UniProt Related Accession: | Q9Y375 |
| Molecular Weight: | 37,764 Da |
| NCBI Full Name: | Complex I intermediate-associated protein 30, mitochondrial |
| NCBI Synonym Full Names: | NADH:ubiquinone oxidoreductase complex assembly factor 1 |
| NCBI Official Symbol: | NDUFAF1 |
| NCBI Official Synonym Symbols: | CGI65; CIA30; CGI-65 |
| NCBI Protein Information: | complex I intermediate-associated protein 30, mitochondrial |
| UniProt Protein Name: | Complex I intermediate-associated protein 30, mitochondrial |
| UniProt Synonym Protein Names: | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 1 |
| UniProt Gene Name: | NDUFAF1 |
| UniProt Entry Name: | CIA30_HUMAN |
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