Human Myostatin Propeptide Recombinant Protein (RPPB0781)

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SKU:
RPPB0781
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
Myostatin Propeptide
Synonyms:
GDF-8
Synonyms:
MSTN
Synonyms:
Growth Differentiation Factor 8
Synonyms:
MSTN Muscle Hypertrophy
Source:
HEK293 Cells
Uniprot:
O14793
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Description

Product Name:Human Myostatin Propeptide Recombinant Protein
Product Code:RPPB0781
Size:10µg
Species:Human
Target:Myostatin Propeptide
Synonyms:GDF-8, MSTN, Growth Differentiation Factor 8, MSTN Muscle Hypertrophy.
Source:HEK293 Cells
Physical Appearance:Filtered colorless solution.
Formulation:Myostatin Propetide solution at a concentration of 0.25mg/ml in phosphate buffered saline (PBS) pH 8.0 and 20% (w/v) glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 80.0% as determined by SDS-PAGE.
Amino Acid Sequence:NENSEQKENV EKEGLCNACT WRQNTKSSRI EAIKIQILSK LRLETAPNIS KDVIRQLLPK APPLRELIDQ YDVQRDDSSD GSLEDDDYHA TTETIITMPT ESDFLMQVDG KPKCCFFKFS SKIQYNKVVK AQLWIYLRPV ETPTTVFVQI LRLIKPMKDG TRYTGIRSLK LDMNPGTGIW QSIDVKTVLQ NWLKQPESNL GIEIKALDEN GHDLAVTFPG PGEDGLNPFL EVKVTDTPKR SRR HHHHHHH HHH

GDF8 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. This gene is thought to encode a secreted protein which negatively regulates skeletal muscle growth.

Myostatin Propetide Human Recombinant produced in HEK cells is a single, glycosylated, polypeptide chain (Asn24-Arg266) containing a total of 253 amino acids, having a calculated molecular mass of 29.1kDa. Myostatin Propetide is fused to a 10 aa C-terminal His tag.

UniProt Protein Function:MSTN: Acts specifically as a negative regulator of skeletal muscle growth. Defects in MSTN are the cause of muscle hypertrophy (MSLHP). MSLHP is a condition characterized by increased muscle bulk and strength. Affected individuals are exceptionally strong. Belongs to the TGF-beta family.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 2q32.2

Cellular Component: extracellular space

Molecular Function:cytokine activity; identical protein binding; protein binding; receptor binding; transforming growth factor beta receptor binding

Biological Process: cell development; muscle development; muscle maintenance; negative regulation of myoblast differentiation; negative regulation of protein kinase B signaling cascade; negative regulation of skeletal muscle growth; positive regulation of transcription, DNA-dependent; regulation of apoptosis; regulation of MAPKKK cascade

Disease: Muscle Hypertrophy

UniProt Code:O14793
NCBI GenInfo Identifier:4885259
NCBI Gene ID:2660
NCBI Accession:NP_005250.1
UniProt Secondary Accession:O14793,Q6B0H2, A1C2J7, A1C2K0,
UniProt Related Accession:O14793
Molecular Weight:42,750 Da
NCBI Full Name:growth/differentiation factor 8 preproprotein
NCBI Synonym Full Names:myostatin
NCBI Official Symbol:MSTN  
NCBI Official Synonym Symbols:GDF8; MSLHP  
NCBI Protein Information:growth/differentiation factor 8
UniProt Protein Name:Growth/differentiation factor 8
UniProt Synonym Protein Names:Myostatin
Protein Family:Growth/differentiation factor
UniProt Gene Name:MSTN  
UniProt Entry Name:GDF8_HUMAN
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