Human MPZL1 Recombinant Protein (RPPB3994)

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SKU:
RPPB3994
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
MPZL1
Synonyms:
Myelin Protein Zero-Like 1
Synonyms:
PZRa
Synonyms:
PZR
Synonyms:
Protein Zero-Related
Source:
Escherichia Coli
Uniprot:
O95297
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Description

Product Name:Human MPZL1 Recombinant Protein
Product Code:RPPB3994
Size:10µg
Species:Human
Target:MPZL1
Synonyms:Myelin Protein Zero-Like 1, PZRa, PZR, Protein Zero-Related, PZRb, Immunoglobulin Family Transmembrane Protein, Myelin Protein Zero-Like Protein 1, MPZL1b, Protein Zero Related, PZR1b.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:The MPZL1 solution contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 1mM DTT and 20% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSLEVYTPK EIFVANGTQG KLTCKFKSTS TTGGLTSVSW SFQPEGADTT VSFFHYSQGQ VYLGNYPPFK DRISWAGDLD KKDASINIEN MQFIHNGTYI CDVKNPPDIV VQPGHIRLYV VEKENLPV 

Myelin Protein Zero-Like 1 (MPZL1) is a cell surface receptor, which is involved in signal transduction processes. MPZL1 recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. MPZL1 is a main receptor for concanavalin-A (ConA) and it is involved in cellular signaling induced by ConA, which most likely includes Src family tyrosine-protein kinases. MPZL1 Isoform 3 appears to have a dominant negative role by blocking tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, might be involved in regulation of integrin-mediated cell motility.

MPZL1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 148 amino acids (38-162) and having a molecular mass of 16.1kDa.MPZL1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:PZR: an immunoglobulin superfamily cell surface protein. Contains two tyrosine-based inhibition motifs (ITIMs) responsible for binding of SHP-2. When phosphorylated, it can specifically bind SHP-2, blocking its translocation, and interupting its function. Treatment of several cell lines with ConA caused tyrosine phosphorylation of PZR. Two alternatively spliced isoforms have been reported. One isoform, PZR1b, lacks the ITIMs and has a dominant negative effect upon full-length PZR and its recruitment of SHP-2.
UniProt Protein Details:

Protein type:Adaptor/scaffold; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q24.2

Cellular Component: focal adhesion; cell surface; integral to plasma membrane

Molecular Function:protein binding; structural molecule activity

Biological Process: cell-cell signaling; transmembrane receptor protein tyrosine kinase signaling pathway

UniProt Code:O95297
NCBI GenInfo Identifier:226054871
NCBI Gene ID:9019
NCBI Accession:NP_001139663.1
UniProt Related Accession:O95297
Molecular Weight:Observed: 29 kDaPredicted: 30 kDa
NCBI Full Name:myelin protein zero-like protein 1 isoform c
NCBI Synonym Full Names:myelin protein zero like 1
NCBI Official Symbol:MPZL1  
NCBI Official Synonym Symbols:PZR; PZRa; PZRb; PZR1b; MPZL1b  
NCBI Protein Information:myelin protein zero-like protein 1
UniProt Protein Name:Myelin protein zero-like protein 1
UniProt Synonym Protein Names:Protein zero-related
UniProt Gene Name:MPZL1  
UniProt Entry Name:MPZL1_HUMAN
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