Human Latexin Recombinant Protein (RPPB1883)
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주문- SKU:
- RPPB1883
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Human
- Target:
- Latexin
- Synonyms:
- LXN
- Synonyms:
- TCI
- Synonyms:
- ECI
- Synonyms:
- Latexin
- Source:
- Escherichia Coli
- Uniprot:
- Q9BS40
Description
| Product Name: | Human Latexin Recombinant Protein |
| Product Code: | RPPB1883 |
| Size: | 20µg |
| Species: | Human |
| Target: | Latexin |
| Synonyms: | LXN, TCI, ECI, Latexin, Endogenous carboxypeptidase inhibitor, Tissue carboxypeptidase inhibitor, MUM. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The Latexin protein solution contains 20mM Tris-HCl, pH-7.5, 50mM NaCl and 10% Glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MEIPPTNYPA SRAALVAQNY INYQQGTPHR VFEVQKVKQA SMEDIPGRGH KYRLKFAVEE IIQKQVKVNC TAEVLYPSTG QETAPEVNFTFEGETGKNPD EEDNTFYQRL KSMKEPLEAQ NIPDNFGNVS PEMTLVLHLA WVACGYIIWQ NSTEDTWYKM VKIQTVKQVQ RNDDFIELDYTILLHNIASQ EIIPWQMQVL WHPQYGTKVK HNSRLPKEVQ LE |
Latexin enzyme is a carboxypeptidase A inhibitor that is highly expressed in the heart, prostate, ovary, kidney, pancrease, brain and colon. Latexin has no noticeable sequence resemblance with plant and parasite inhibitors, however it is related to a human putative tumor suppressor protein, TIG1. Latexin is down-regulated in the presenilin-1-deficient mouse brain, thus putatively playing a role in Alzheimer's disease.
Recombinant Human Latexin produced in E.Coli is a single, non-glycosylated polypeptide chain containing 222 amino acids and having a molecular mass of 25.7kDa. Latexin is purified by conventional chromatography techniques.
| UniProt Protein Function: | LXN: Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. Belongs to the protease inhibitor I47 (latexin) family. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 3q25.32 Molecular Function:protein binding |
| NCBI Summary: | This gene encodes the only known protein inhibitor of zinc-dependent metallocarboxypeptidases. [provided by RefSeq, Oct 2008] |
| UniProt Code: | Q9BS40 |
| NCBI GenInfo Identifier: | 146345452 |
| NCBI Gene ID: | 56925 |
| NCBI Accession: | Q9BS40.2 |
| UniProt Secondary Accession: | Q9BS40,Q96PN2, Q9NQS6, |
| UniProt Related Accession: | Q9BS40 |
| Molecular Weight: | 25,750 Da |
| NCBI Full Name: | Latexin |
| NCBI Synonym Full Names: | latexin |
| NCBI Official Symbol: | LXN |
| NCBI Official Synonym Symbols: | ECI; TCI |
| NCBI Protein Information: | latexin |
| UniProt Protein Name: | Latexin |
| UniProt Synonym Protein Names: | Endogenous carboxypeptidase inhibitor; ECI; Protein MUM; Tissue carboxypeptidase inhibitor; TCI |
| Protein Family: | Latexin |
| UniProt Gene Name: | LXN |
| UniProt Entry Name: | LXN_HUMAN |
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