Human LAIR2 Recombinant Protein (RPPB5900)

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SKU:
RPPB5900
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
LAIR2
Synonyms:
Leukocyte-associated immunoglobulin-like receptor 2
Synonyms:
LAIR-2
Synonyms:
CD306
Synonyms:
LAIR2
Source:
Escherichia Coli
Uniprot:
Q6ISS4
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Description

Product Name:Human LAIR2 Recombinant Protein
Product Code:RPPB5900
Size:20µg
Species:Human
Target:LAIR2
Synonyms:Leukocyte-associated immunoglobulin-like receptor 2, LAIR-2, CD306, LAIR2.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:LAIR2 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 20% glycerol, 0.1M NaCl and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMQEGAL PRPSISAEPG TVISPGSHVT FMCRGPVGVQ TFRLEREDRA KYKDSYNVFR LGPSESEARF HIDSVSEGNA GLYRCLYYKP PGWSEHSDFL ELLVKGTVPG TEASGFDAP

Leukocyte-associated immunoglobulin-like receptor 2 (LAIR2) is a secreted, 131 amino acids protein which contains one IglikeC2 type domain, rendering it a member of the Ig superfamily. Even though one is secreted and one is membrane bound, the 2 LAIR proteins are assumed to have evolved from a common gene ancestor and seem to share similar adhesion profiles, suggesting that LAIR2 may compete with LAIR1 for ligand binding. LAIR2 was discovered by its similarity to LAIR1, which is an inhibitory receptor present on mononuclear leukocytes. The LAIR2 gene maps to a region of 19q13.4, dubbed the leukocyte receptor cluster, which contains 29 genes in the immunoglobulin superfamily, including LAIR1. The function of the LAIR2 protein is unknown, though it is assumed to be secreted and may help modulate mucosal tolerance.

LAIR2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 139 amino acids (22-135 a.a) and having a molecular mass of 15.2kDa.LAIR2 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:LAIR-2: 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 19q13.4

Cellular Component: extracellular region

NCBI Summary:The protein encoded by this gene is a member of the immunoglobulin superfamily. It was identified by its similarity to LAIR1, an inhibitory receptor present on mononuclear leukocytes. This gene maps to a region of 19q13.4, termed the leukocyte receptor cluster, which contains 29 genes in the immunoglobulin superfamily, including LAIR1. The function of this protein is unknown, although it is thought to be secreted and may help modulate mucosal tolerance. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
UniProt Code:Q6ISS4
NCBI GenInfo Identifier:10947101
NCBI Gene ID:3904
NCBI Accession:NP_002279.2
UniProt Secondary Accession:Q6ISS4,Q6PEZ4,
UniProt Related Accession:Q6ISS4
Molecular Weight:
NCBI Full Name:leukocyte-associated immunoglobulin-like receptor 2 isoform a
NCBI Synonym Full Names:leukocyte-associated immunoglobulin-like receptor 2
NCBI Official Symbol:LAIR2  
NCBI Official Synonym Symbols:CD306; MGC71634  
NCBI Protein Information:leukocyte-associated immunoglobulin-like receptor 2; LAIR-2; OTTHUMP00000068389; OTTHUMP00000068390; leukocyte-associated Ig-like receptor 2; leukocyte-associated Ig-like receptor-2
UniProt Protein Name:Leukocyte-associated immunoglobulin-like receptor 2
Protein Family:Leukocyte-associated immunoglobulin-like receptor
UniProt Gene Name:
UniProt Entry Name:LAIR2_HUMAN
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