Human IL 6 Recombinant Protein (RPPB0522)

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SKU:
RPPB0522
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
IL 6
Synonyms:
B cell differentiation factor
Synonyms:
BCDF
Synonyms:
BSF-2
Synonyms:
HPGF
Source:
Escherichia Coli
Uniprot:
P05231
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Description

Product Name:Human IL 6 Recombinant Protein
Product Code:RPPB0522
Size:20µg
Species:Human
Target:IL 6
Synonyms:B cell differentiation factor, BCDF, BSF-2, HPGF, HSF, MGI-2, B-cell stimulatory factor 2,Hybridoma growth factor, CTL differentiation factor, CDF, IL-6, HGF.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:Lyophilized from a 0.2um filtered concentrated (1mg/ml) solution in PBS, pH 7.4.
Solubility:It is recommended to reconstitute the lyophilized Interleukin-6 in sterile 18M?-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized Interleukin-6 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL6 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Purity:Greater than 97.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
Amino Acid Sequence:The sequence of the first five N-terminal amino acids was determined and was found to be Met-Pro-Val-Pro-Pro
Biological Activity:The ED50 as determined by the dose-dependant stimulation of murine 7TD1 cells is less than 0.1 ng/ml, corresponding to the specific activity of 1.0 x 10,000,000 Units per mg.

Il-6 is a cytokine with a wide variety of biological functions: it plays an essential role in the final differentiation of b-cells into ig-secreting cells, it induces myeloma and plasmacytoma growth, it induces nerve cells differentiation, in hepatocytes it induces acute phase reactants.

Interleukin-6 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 184 amino acids and having a molecular mass of 21000 Dalton. The IL6 is purified by proprietary chromatographic techniques.

UniProt Code:P05231
NCBI GenInfo Identifier:124347
NCBI Gene ID:3569
NCBI Accession:P05231.1
UniProt Secondary Accession:P05231,Q9UCU2, Q9UCU3, Q9UCU4,
UniProt Related Accession:P05231
Molecular Weight:212
NCBI Full Name:Interleukin-6
NCBI Synonym Full Names:interleukin 6
NCBI Official Symbol:IL6  
NCBI Official Synonym Symbols:HGF; HSF; BSF2; IL-6; IFNB2  
NCBI Protein Information:interleukin-6; CDF; BSF-2; IFN-beta-2; interferon beta-2; interleukin BSF-2; interferon, beta 2; hybridoma growth factor; CTL differentiation factor; B-cell stimulatory factor 2; B-cell differentiation factor
UniProt Protein Name:Interleukin-6
UniProt Synonym Protein Names:B-cell stimulatory factor 2; BSF-2; CTL differentiation factor; CDF; Hybridoma growth factor; Interferon beta-2; IFN-beta-2
Protein Family:Interleukin
UniProt Gene Name:IL6  
UniProt Entry Name:IL6_HUMAN
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