Human HINT2 Recombinant Protein (RPPB3684)

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SKU:
RPPB3684
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
HINT2
Synonyms:
Histidine triad nucleotide-binding protein 2 mitochondrial
Synonyms:
HINT-2
Synonyms:
HINT-3 HIT-17kDa
Synonyms:
PKCI-1-related HIT protein
Source:
Escherichia Coli
Uniprot:
Q9BX68
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Description

Product Name:Human HINT2 Recombinant Protein
Product Code:RPPB3684
Size:10µg
Species:Human
Target:HINT2
Synonyms:Histidine triad nucleotide-binding protein 2 mitochondrial, HINT-2, HINT-3 HIT-17kDa, PKCI-1-related HIT protein, HINT2, histidine triad nucleotide binding protein 2, HIT-17.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:HINT2 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSVAATGVR GGQVRGAAGV TDGNEVAKAQ QATPGGAAPT IFSRILDKSL PADILYEDQQ CLVFRDVAPQ APVHFLVIPK KPIPRISQAE EEDQQLLGHL LLVAKQTAKA EGLGDGYRLV INDGKLGAQS VYHLHIHVLG GRQLQWPPG

Histidine triad nucleotide-binding protein 2 (HINT2) belongs to the triad proteins, which are nucleotide hydrolases and transferases that act on the alpha-phosphate of ribonucleotides. Hydrolase is most likely involved in steroid biosynthesis, furthermore it might play a role in apoptosis. HINT2 shows high expression in liver and pancreas. Expression is significantly down-regulated in hepatocellular carcinoma (HCC) patients.

HINT2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 169 amino acids (18-163 a.a) and having a molecular mass of 17.9kDa.HINT2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:HINT2: Hydrolase probably involved in steroid biosynthesis. May play a role in apoptosis. Has adenosine phosphoramidase activity. Belongs to the HINT family.Protein type: Hydrolase; EC 3.-.-.-Chromosomal Location of Human Ortholog: 9p13.3Cellular Component: mitochondrion; nucleolusMolecular Function: hydrolase activity; nucleotide bindingBiological Process: apoptosis; steroid biosynthetic process
UniProt Protein Details:
NCBI Summary:Histidine triad proteins, such as HINT2, are nucleotide hydrolases and transferases that act on the alpha-phosphate of ribonucleotides (Brenner, 2002 [PubMed 12119013]).[supplied by OMIM, Mar 2008]
UniProt Code:Q9BX68
NCBI GenInfo Identifier:14211923
NCBI Gene ID:84681
NCBI Accession:NP_115982.1
UniProt Secondary Accession:Q9BX68,Q5TCW3
UniProt Related Accession:Q9BX68
Molecular Weight:17,162 Da
NCBI Full Name:histidine triad nucleotide-binding protein 2, mitochondrial
NCBI Synonym Full Names:histidine triad nucleotide binding protein 2
NCBI Official Symbol:HINT2  
NCBI Official Synonym Symbols:HIT-17  
NCBI Protein Information:histidine triad nucleotide-binding protein 2, mitochondrial; HINT-2; HINT-3; HIT-17kDa; PKCI-1-related HIT protein; protein kinase C inhibitor-2
UniProt Protein Name:Histidine triad nucleotide-binding protein 2, mitochondrial
UniProt Synonym Protein Names:HINT-3; HIT-17kDa; PKCI-1-related HIT protein
Protein Family:Histidine triad nucleotide-binding protein
UniProt Gene Name:HINT2  
UniProt Entry Name:HINT2_HUMAN
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