Human DLK1 Recombinant Protein (RPPB3354)

(No reviews yet) Write a Review

제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.

주문
SKU:
RPPB3354
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
DLK1
Synonyms:
DLK1
Synonyms:
Delta-Like 1 Homolog (Drosophila)
Synonyms:
PREF1
Synonyms:
DLK-1
Source:
Sf9 Insect cells
Uniprot:
P80370
€0.00
Frequently bought together:

Description

Product Name:Human DLK1 Recombinant Protein
Product Code:RPPB3354
Size:10µg
Species:Human
Target:DLK1
Synonyms:DLK1, Delta-Like 1 Homolog (Drosophila), PREF1, DLK-1, FA1, DLK, PG2, Delta-Like Homolog (Drosophila), Protein Delta Homolog 1, Preadipocyte Factor 1, Fetal Antigen 1, Secredeltin, DELTA1, Pref-1, ZOG.
Source:Sf9 Insect cells
Physical Appearance:Sterile Filtered clear solution.
Formulation:DLK1 protein solution (0.25mg/ml) containing Phosphate Buffered Saline (pH7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:AECFPACNPQ NGFCEDDNVC RCQPGWQGPL CDQCVTSPGC LHGLCGEPGQ CICTDGWDGE LCDRDVRACS SAPCANNGTC VSLDDGLYEC SCAPGYSGKD CQKKDGPCVI NGSPCQHGGT CVDDEGRASH ASCLCPPGFS GNFCEIVANS CTPNPCENDG VCTDIGGDFR CRCPAGFIDK TCSRPVTNCA SSPCQNGGTC LQHTQVSYEC LCKPEFTGLT CVKKRALSPQ QVTRLPSGYG LAYRLTPGVH ELPVQQPEHR ILKVSMKELN KKTPLLTEGQ LEHHHHHH

Delta-Like 1, also known as DLK1 is amember of the Notch/Delta/Serrate family of epidermal growth factor (EGF)-likerepeat-containing proteins which act as ligands in the Notch signaling pathway.Furthermore, DLK1 has six highly conserved epidermal-growth-factor motifs andit also contains up to ten O-glycosylation and N-glycosylation locations, sixof them are differentially glycosylated.

DLK1 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated  polypeptide chain containing 288 amino acids (24-303 a.a) and having a molecular mass of 30.7kDa.DLK1 is fused to an 8 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:DLK1: May have a role in neuroendocrine differentiation. Monomer. Found within the stromal cells in close contact to the vascular structure of placental villi, yolk sac, fetal liver, adrenal cortex and pancreas and in the beta cells of the islets of Langerhans in the adult pancreas. Found also in some forms of neuroendocrine lung tumor tissue. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: 14q32

Cellular Component: extracellular space

Biological Process: negative regulation of Notch signaling pathway

NCBI Summary:This gene encodes a transmembrane protein that contains multiple epidermal growth factor repeats that functions as a regulator of cell growth. The encoded protein is involved in the differentiation of several cell types including adipocytes. This gene is located in a region of chromosome 14 frequently showing unparental disomy, and is imprinted and expressed from the paternal allele. A single nucleotide variant in this gene is associated with child and adolescent obesity and shows polar overdominance, where heterozygotes carrying an active paternal allele express the phenotype, while mutant homozygotes are normal. [provided by RefSeq, Nov 2015]
UniProt Code:P80370
NCBI GenInfo Identifier:296439371
NCBI Gene ID:8788
NCBI Accession:P80370.3
UniProt Secondary Accession:P80370,P15803, Q96DW5,
UniProt Related Accession:P80370
Molecular Weight:33,067 Da
NCBI Full Name:Protein delta homolog 1
NCBI Synonym Full Names:delta like non-canonical Notch ligand 1
NCBI Official Symbol:DLK1  
NCBI Official Synonym Symbols:DLK; FA1; ZOG; pG2; DLK-1; PREF1; Delta1; Pref-1  
NCBI Protein Information:protein delta homolog 1
UniProt Protein Name:Protein delta homolog 1
UniProt Synonym Protein Names:pG2
Protein Family:Protein
UniProt Gene Name:DLK1  
UniProt Entry Name:DLK1_HUMAN
View AllClose

Related Products