Human DIMT1 Recombinant Protein (RPPB1576)

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SKU:
RPPB1576
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
DIMT1
Synonyms:
Probable dimethyladenosine transferase
Synonyms:
DIM1 dimethyladenosine transferase 1 homolog
Synonyms:
DIM1 dimethyladenosine transferase 1-like
Synonyms:
Probable 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase
Source:
Escherichia Coli
Uniprot:
Q9UNQ2
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Description

Product Name:Human DIMT1 Recombinant Protein
Product Code:RPPB1576
Size:20µg
Species:Human
Target:DIMT1
Synonyms:Probable dimethyladenosine transferase, DIM1 dimethyladenosine transferase 1 homolog, DIM1 dimethyladenosine transferase 1-like, Probable 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase, Probable 18S rRNA dimethylase, Probable S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase, DIMT1, DIMT1L, HUSSY-05, HSA9761.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The DIMT1 solution (0.25mg/ml) contains 20mM Tris-HCl buffer, pH8.0, 30% glycerol, 2mM DTT, 200mM NaCl and 2mM EDTA.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MMPKVKSGAI GRRRGRQEQR RELKSAGGLM FNTGIGQHIL KNPLIINSII DKAALRPTDV VLEVGPGTGN MTVKLLEKAK KVVACELDPR LVAELHKRVQ GTPVASKLQV LVGDVLKTDL PFFDTCVANL PYQISSPFVF KLLLHRPFFR CAILMFQREF ALRLVAKPGD KLYCRLSINT QLLARVDHLM KVGKNNFRPP PKVESSVVRI EPKNPPPPIN FQEWDGLVRI TFVRKNKTLS AAFKSSAVQQ LLEKNYRIHC SVHNIIIPED FSIADKIQQI LTSTGFSDKR ARSMDIDDFI RLLHGFNAEG IHFS

DIM1 dimethyladenosine transferase 1 homolog (DIMT1) is a member of the methyltransferase superfamily. The DIMT1 enzyme specifically dimethylates 2 adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle. DIMT1 is restricted to the nucleolus.

DIMT1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 334 amino acids (1-313) and having a molecular mass of 37.5kDa.DIMT1 is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:DIMT1: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle. Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
UniProt Protein Details:

Protein type:EC 2.1.1.183; Nucleolus; RNA-binding; Methyltransferase

Chromosomal Location of Human Ortholog: 5q12.1

Cellular Component: cytoplasm; nucleolus; nucleus

Molecular Function:rRNA (adenine-N6,N6-)-dimethyltransferase activity

Biological Process: rRNA methylation

NCBI Summary:The protein encoded by this gene is a methyltransferase that is responsible for dimethylation of adjacent adenosines near the 18S rRNA decoding site. The encoded protein is essential for ribosome biogenesis, although its catalytic activity is not involved in the process. The yeast ortholog of this protein functions in the cytoplasm while this protein functions in the nucleus. [provided by RefSeq, Jan 2017]
UniProt Code:Q9UNQ2
NCBI GenInfo Identifier:27151492
NCBI Gene ID:27292
NCBI Accession:Q9UNQ2.1
UniProt Related Accession:Q9UNQ2
Molecular Weight:35 kDa
NCBI Full Name:Probable dimethyladenosine transferase
NCBI Synonym Full Names:DIMT1 rRNA methyltransferase and ribosome maturation factor
NCBI Official Symbol:DIMT1  
NCBI Official Synonym Symbols:DIM1; DIMT1L; HUSSY5; HSA9761  
NCBI Protein Information:probable dimethyladenosine transferase
UniProt Protein Name:Probable dimethyladenosine transferase
UniProt Synonym Protein Names:DIM1 dimethyladenosine transferase 1 homolog; DIM1 dimethyladenosine transferase 1-like; Probable 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase; Probable 18S rRNA dimethylase; Probable S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase
Protein Family:Probable dimethyladenosine transferase
UniProt Gene Name:DIMT1  
UniProt Entry Name:DIM1_HUMAN
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