Human DDAH1 Recombinant Protein (RPPB1562)
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주문- SKU:
- RPPB1562
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Human
- Target:
- DDAH1
- Synonyms:
- DDAH
- Synonyms:
- DDAH-1
- Source:
- Escherichia Coli
- Uniprot:
- O94760
Description
| Product Name: | Human DDAH1 Recombinant Protein |
| Product Code: | RPPB1562 |
| Size: | 20µg |
| Species: | Human |
| Target: | DDAH1 |
| Synonyms: | DDAH, DDAH-1, Dimethylargininase-1, dimethylargininase-1, Dimethylarginine Dimethylaminohydrolase 1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The DDAH1 protein solution (1mg/1ml) is formulated in 20mM Tris-HCl buffer (pH 8.0) 1mM DTT, 50mM NaCl and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMAGLGHP AAFGRATHAV VRALPESLGQ HALRSAKGEE VDVARAERQH QLYVGVLGSK LGLQVVELPA DESLPDCVFV EDVAVVCEET ALITRPGAPS RRKEVDMMKE ALEKLQLNIV EMKDENATLD GGDVLFTGRE FFVGLSKRTN QRGAEILADT FKDYAVSTVP VADGLHLKSF CSMAGPNLIA IGSSESAQKA LKIMQQMSDH RYDKLTVPDD IAANCIYLNI PNKGHVLLHR TPEEYPESAK VYEKLKDHML IPVSMSELEK VDGLLTCCSV LINKKVDS |
Dimethylarginine dimethylaminohydrolase 1, is a part of the Dimethylarginine Dimethylaminohydrolase gene family. DDAH1 participates in nitric oxide generation by regulating cellular concentrations of methylarginines, that in turn inhibit nitric oxide synthase activity. Deficiency of DDAH1 results in ADMA (asymmetric dimethylarginine) increase and a decrease in cGMP generation.
DDAH1 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 308 amino acids (1-285a.a.) and having a molecular mass of 33.5kDa.DDAH1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | DDAH1: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation. Belongs to the DDAH family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.5.3.18; Hydrolase Chromosomal Location of Human Ortholog: 1p22.3 Cellular Component: cytosol Molecular Function:catalytic activity; dimethylargininase activity Biological Process: citrulline metabolic process; nitric oxide mediated signal transduction; positive regulation of nitric oxide biosynthetic process; regulation of nitric-oxide synthase activity; regulation of systemic arterial blood pressure |
| NCBI Summary: | This gene belongs to the dimethylarginine dimethylaminohydrolase (DDAH) gene family. The encoded enzyme plays a role in nitric oxide generation by regulating cellular concentrations of methylarginines, which in turn inhibit nitric oxide synthase activity. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O94760 |
| NCBI GenInfo Identifier: | 6831528 |
| NCBI Gene ID: | 23576 |
| NCBI Accession: | O94760.3 |
| UniProt Secondary Accession: | O94760,Q5HYC8, Q86XK5, |
| UniProt Related Accession: | O94760 |
| Molecular Weight: | 31kDa |
| NCBI Full Name: | N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 |
| NCBI Synonym Full Names: | dimethylarginine dimethylaminohydrolase 1 |
| NCBI Official Symbol: | DDAH1 |
| NCBI Official Synonym Symbols: | DDAH; DDAHI; DDAH-1; HEL-S-16 |
| NCBI Protein Information: | N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 |
| UniProt Protein Name: | N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 |
| UniProt Synonym Protein Names: | DDAHI; Dimethylargininase-1 |
| Protein Family: | N(G),N(G)-dimethylarginine dimethylaminohydrolase |
| UniProt Gene Name: | DDAH1 |
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