Human DCUN1D1 Recombinant Protein (RPPB3340)

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SKU:
RPPB3340
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
DCUN1D1
Synonyms:
DCN1
Synonyms:
defective in cullin neddylation 1-domain containing 1 (S cerevisiae)
Synonyms:
RP42
Synonyms:
DCUN1L1
Source:
Escherichia Coli
Uniprot:
Q96GG9
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Description

Product Name:Human DCUN1D1 Recombinant Protein
Product Code:RPPB3340
Size:20µg
Species:Human
Target:DCUN1D1
Synonyms:DCN1, defective in cullin neddylation 1-domain containing 1 (S. cerevisiae), RP42, DCUN1L1, SCCRO, SCRO, Tes3, Defective in cullin neddylation protein 1-like protein 1, Squamous cell carcinoma-related oncogene, DCUN1 domain-containing protein 1, DCN1-like protein 1, RP42 homolog.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The DCUN1D1 protein solution (1mg/1ml) is formulated in 20mM Tris-HCl buffer (pH8.0) 0.1M NaCl and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.Please avoid freeze thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MNKLKSSQKD KVRQFMIFTQ SSEKTAVSCL SQNDWKLDVA TDNFFQNPEL YIRESVKGSL DRKKLEQLYN RYKDPQDENK IGIDGIQQFC DDLALDPASI SVLIIAWKFR AATQCEFSKQ EFMDGMTELG CDSIEKLKAQ IPKMEQELKE PGRFKDFYQF TFNFAKNPGQ KGLDLEMAIA YWNLVLNGRF KFLDLWNKFL LEHHKRSIPK DTWNLLLDFS TMIADDMSNY DEEGAWPVLI DDFVEFARPQ IAGTKSTTV

DCUN1D1 takes part in the malignant transformation of squamous cell lineage. DCUN1D1 protein regulates Gli1, a main regulator of the hedgehog (HH) pathway which takes a vital role in development, maintenance, and regeneration of practically all adult tissues.

DCUN1D1 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 279 amino acids (1-259a.a.) and having a molecular mass of 32.2kDa. DCUN1D1 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:DCUN1D1: Part of an E3 ubiquitin ligase complex for neddylation. Required for neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes by enhancing the rate of cullins neddylation. Functions to recruit the NEDD8-charged E2 enzyme to the cullin component. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression.
UniProt Protein Details:

Protein type:Oncoprotein; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 3q26.3

Cellular Component: nucleus; ubiquitin ligase complex

Molecular Function:protein binding; small conjugating protein binding; ubiquitin conjugating enzyme binding

Biological Process: positive regulation of ubiquitin-protein ligase activity; protein neddylation

UniProt Code:Q96GG9
NCBI GenInfo Identifier:809281410
NCBI Gene ID:54165
NCBI Accession:NP_001295030.1
UniProt Secondary Accession:Q96GG9,Q7L3G9, Q8TEX7, Q9H6M1, Q9HCT3, B2RB37,
UniProt Related Accession:Q96GG9
Molecular Weight:30,124 Da
NCBI Full Name:DCN1-like protein 1 isoform 2
NCBI Synonym Full Names:defective in cullin neddylation 1 domain containing 1
NCBI Official Symbol:DCUN1D1  
NCBI Official Synonym Symbols:RP42; SCRO; Tes3; DCNL1; SCCRO; DCUN1L1  
NCBI Protein Information:DCN1-like protein 1
UniProt Protein Name:DCN1-like protein 1
UniProt Synonym Protein Names:DCUN1 domain-containing protein 1; Defective in cullin neddylation protein 1-like protein 1; Squamous cell carcinoma-related oncogene
Protein Family:DCN1-like protein
UniProt Gene Name:DCUN1D1  
UniProt Entry Name:DCNL1_HUMAN
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