Human CNDP2 Recombinant Protein (RPPB1501)

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SKU:
RPPB1501
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
CNDP2
Synonyms:
Cytosolic non-specific dipeptidase
Synonyms:
CNDP dipeptidase 2
Synonyms:
CN2
Synonyms:
CPGL
Source:
Escherichia Coli
Uniprot:
Q96KP4
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Description

Product Name:Human CNDP2 Recombinant Protein
Product Code:RPPB1501
Size:20µg
Species:Human
Target:CNDP2
Synonyms:Cytosolic non-specific dipeptidase, CNDP dipeptidase 2, CN2, CPGL, HsT2298, PEPA, Glutamate carboxypeptidase-like protein 1, Peptidase A.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The CNDP2 solution (1mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl, 10% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMAALTTL FKYIDENQDR YIKKLAKWVA IQSVSAWPEK RGEIRRMMEV AAADVKQLGG SVELVDIGKQ KLPDGSEIPL PPILLGRLGS DPQKKTVCIY GHLDVQPAAL EDGWDSEPFT LVERDGKLYG RGSTDDKGPV AGWINALEAY QKTGQEIPVN VRFCLEGMEE SGSEGLDELI FARKDTFFKD VDYVCISDNY WLGKKKPCIT YGLRGICYFF IEVECSNKDL HSGVYGGSVH EAMTDLILLM GSLVDKRGNI LIPGINEAVA AVTEEEHKLY DDIDFDIEEF AKDVGAQILL HSHKKDILMH RWRYPSLSLH GIEGAFSGSG AKTVIPRKVV GKFSIRLVPN MTPEVVGEQV TSYLTKKFAE LRSPNEFKVY MGHGGKPWVS DFSHPHYLAG RRAMKTVFGV EPDLTREGGS IPVTLTFQEA TGKNVMLLPV GSADDGAHSQ NEKLNRYNYI EGTKMLAAYL YEVSQLKD

CNDP Dipeptidase 2 (CNDP2), is a cytosolic, non-specific dipeptidase which is a part of the peptidase M20A protein family. CNDP2 is a secreted peptidase homologous to M20 peptidases. CNDP2 expresses through all adult and fetal tissue, though, an isoform missing exons 3 and 4 expresses in all fetal tissue in adult liver. Over expression of CPGL-B in hepatocellular carcinoma cells results in significant inhibition of HC cell viability, colony formation, cell invasiveness and tumor configuration.

CNDP2 Human Recombinant produced in E. coli is a single polypeptide chain containing 498 amino acids (1-475) and having a molecular mass of 55.3 kDa. CNDP2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:CNDP2: Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. Isoform 2 may be play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells. Belongs to the peptidase M20A family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 3.4.13.18; Protease

Chromosomal Location of Human Ortholog: 18q22.3

Cellular Component: cytosol; nucleoplasm

Molecular Function:carboxypeptidase activity

Biological Process: glutathione biosynthetic process; sulfur amino acid metabolic process

NCBI Summary:CNDP2, also known as tissue carnosinase and peptidase A (EC 3.4.13.18), is a nonspecific dipeptidase rather than a selective carnosinase (Teufel et al., 2003 [PubMed 12473676]).[supplied by OMIM, Mar 2008]
UniProt Code:Q96KP4
NCBI GenInfo Identifier:23396498
NCBI Gene ID:55748
NCBI Accession:Q96KP4.2
UniProt Secondary Accession:Q96KP4,Q8WY59, Q9BQ94, Q9NVB4, B3KUG4, V9HWE5,
UniProt Related Accession:Q96KP4
Molecular Weight:53kDa
NCBI Full Name:Cytosolic non-specific dipeptidase
NCBI Synonym Full Names:carnosine dipeptidase 2
NCBI Official Symbol:CNDP2  
NCBI Official Synonym Symbols:CN2; CPGL; PEPA; HsT2298; HEL-S-13  
NCBI Protein Information:cytosolic non-specific dipeptidase
UniProt Protein Name:Cytosolic non-specific dipeptidase
UniProt Synonym Protein Names:CNDP dipeptidase 2; Carnosine dipeptidase II
Protein Family:Cytosolic non-specific dipeptidase
UniProt Gene Name:CNDP2  
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