Human CIAO1 Recombinant Protein (RPPB3184)

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SKU:
RPPB3184
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
CIAO1
Synonyms:
CIA1
Synonyms:
WDR39
Synonyms:
Probable cytosolic iron-sulfur protein assembly protein CIAO1
Synonyms:
WD repeat-containing protein 39
Source:
Escherichia Coli
Uniprot:
O76071
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Description

Product Name:Human CIAO1 Recombinant Protein
Product Code:RPPB3184
Size:20µg
Species:Human
Target:CIAO1
Synonyms:CIA1, WDR39, Probable cytosolic iron-sulfur protein assembly protein CIAO1, WD repeat-containing protein 39, CIAO1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:CIAO1 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 20% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMKDSLVL LGRVPAHPDS RCWFLAWNPA GTLLASCGGD RRIRIWGTEG DSWICKSVLS EGHQRTVRKV AWSPCGNYLA SASFDATTCI WKKNQDDFEC VTTLEGHENE VKSVAWAPSG NLLATCSRDK SVWVWEVDEE DEYECVSVLN SHTQDVKHVV WHPSQELLAS ASYDDTVKLY REEEDDWVCC ATLEGHESTV WSLAFDPSGQ RLASCSDDRT VRIWRQYLPG NEQGVACSGS DPSWKCICTL SGFHSRTIYD IAWCQLTGAL ATACGDDAIR VFQEDPNSDP QQPTFSLTAH LHQAHSQDVN CVAWNPKEPG LLASCSDDGE VAFWKYQRPE GL

CIAO1 is a vital component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. CIAO1 protein is required for the maturation of extra mitochondrial Fe/S proteins and seems to specifically modulate the trans-activation activity of WT1. CIAO1 participates in chromosome segregation as a part of the mitotic spindle-associated MMXD complex.

CIAO1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 362 amino acids (1-339a.a) and having a molecular mass of 40kDa. CIAO1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:CIAO1: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation. Belongs to the WD repeat CIA1 family.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 2q11.2

Biological Process: regulation of transcription from RNA polymerase II promoter; iron-sulfur cluster assembly; positive regulation of cell proliferation; chromosome segregation

UniProt Code:O76071
NCBI GenInfo Identifier:12229745
NCBI Gene ID:9391
NCBI Accession:O76071.1
UniProt Secondary Accession:O76071,Q53FM5, A0MNN9,
UniProt Related Accession:O76071
Molecular Weight:339
NCBI Full Name:Probable cytosolic iron-sulfur protein assembly protein CIAO1
NCBI Synonym Full Names:cytosolic iron-sulfur assembly component 1
NCBI Official Symbol:CIAO1  
NCBI Official Synonym Symbols:CIA1; WDR39  
NCBI Protein Information:probable cytosolic iron-sulfur protein assembly protein CIAO1; WD40 protein Ciao1; WD repeat domain 39; WD repeat-containing protein 39; cytosolic iron-sulfur protein assembly 1 homolog
UniProt Protein Name:Probable cytosolic iron-sulfur protein assembly protein CIAO1
UniProt Synonym Protein Names:WD repeat-containing protein 39
Protein Family:Probable cytosolic iron-sulfur protein assembly protein
UniProt Gene Name:CIAO1  
UniProt Entry Name:CIAO1_HUMAN
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