Human CD69 Recombinant Protein (RPPB3088)

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SKU:
RPPB3088
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
CD69
Synonyms:
CD69Molecule
Synonyms:
CD69 Antigen (P60
Synonyms:
Early T-Cell Activation Antigen)
Synonyms:
Early T-CellActivation Antigen P60
Source:
Sf9 Insect cells
Uniprot:
Q07108
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Description

Product Name:Human CD69 Recombinant Protein
Product Code:RPPB3088
Size:10µg
Species:Human
Target:CD69
Synonyms:CD69Molecule, CD69 Antigen (P60, Early T-Cell Activation Antigen), Early T-CellActivation Antigen P60, Leukocyte Surface Antigen Leu-23, BL-AC/P26, GP32/28, CLEC2C,MLR-3, AIM, EA1, C-Type Lectin Domain Family 2, Member C, Activation InducerMolecule (AIM/CD69), C-Type Lectin Domain Family 2 Member C, Early LymphocyteActivation Antigen, Activation Inducer Molecule, CD69 Antigen, Early activationantigen CD69.
Source:Sf9 Insect cells
Physical Appearance:Sterile Filtered clear solution.
Formulation:CD69 protein solution (0.5mg/ml) contains PhosphateBuffered Saline (pH 7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:ADPSVGQYNC PGQYTFSMPSDSHVSSCSED WVGYQRKCYF ISTVKRSWTS AQNACSEHGA TLAVIDSEKD MNFLKRYAGR EEHWVGLKKE PGHPWKWSNGKEFNNWFNVT GSDKCVFLKN TEVSSMECEK NLYWICNKPY KHHHHHH

CD69 is a type 2 transmembrane glycoprotein which belongs to the C-typelectin family. CD69 is a very early activation Ag of T lymphocytes. The expressionof CD69 is induced upon activation of T lymphocytes, and CD69 takes part inproliferation. Moreover, CD69 acts to transmit signals in natural killer cellsas well as platelets. CD69 functions in the pathogenesis of allergen induced eosinophilicairway inflammation and responsiveness. Among the diseases which are associatedwith CD69: cd3gamma deficiency and mast cell disease.

CD69 produced in Sf9 Baculovirus cells is a single,glycosylated polypeptide chain containing 147 amino acids (62-199a.a.) andhaving a molecular mass of 17.0kDa. (Molecular size on SDS-PAGE will appear atapproximately 18-28kDa).CD69 is expressed with a 6 amino acid His tag atC-Terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:Function: Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets.
UniProt Protein Details:

Subunit structure: Homodimer; disulfide-linked. Ref.6 Ref.7 Ref.8

Subcellular location: Membrane; Single-pass type II membrane protein.

Tissue specificity: Expressed on the surface of activated T-cells, B-cells, natural killer cells, neutrophils, eosinophils, epidermal Langerhans cells and platelets.

Developmental stage: Earliest inducible cell surface glycoprotein acquired during lymphoid activation.

Induction: By antigens, mitogens or activators of PKC on the surface of T and B-lymphocytes. By interaction of IL-2 with the p75 IL-2R on the surface of NK cells.

Post-translational modification: Constitutive Ser/Thr phosphorylation in both mature thymocytes and activated T-lymphocytes.

Sequence similarities: Contains 1 C-type lectin domain.

NCBI Summary:This gene encodes a member of the calcium dependent lectin superfamily of type II transmembrane receptors. Expression of the encoded protein is induced upon activation of T lymphocytes, and may play a role in proliferation. Furthermore, the protein may act to transmit signals in natural killer cells and platelets. [provided by RefSeq, Aug 2011]
UniProt Code:Q07108
NCBI GenInfo Identifier:584906
NCBI Gene ID:969
NCBI Accession:Q07108.1
UniProt Related Accession:Q07108
Molecular Weight:22,559 Da
NCBI Full Name:Early activation antigen CD69
NCBI Synonym Full Names:CD69 molecule
NCBI Official Symbol:CD69  
NCBI Official Synonym Symbols:AIM; EA1; MLR-3; CLEC2C; GP32/28; BL-AC/P26  
NCBI Protein Information:early activation antigen CD69; leukocyte surface antigen Leu-23; early T-cell activation antigen p60; early lymphocyte activation antigen; activation inducer molecule (AIM/CD69); C-type lectin domain family 2, member C; CD69 antigen (p60, early T-cell act
UniProt Protein Name:Early activation antigen CD69
UniProt Synonym Protein Names:Activation inducer molecule; AIM; BL-AC/P26; C-type lectin domain family 2 member C; EA1; Early T-cell activation antigen p60; GP32/28; Leukocyte surface antigen Leu-23; MLR-3
UniProt Gene Name:CD69  
UniProt Entry Name:CD69_HUMAN
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