Human CD300A Recombinant Protein (RPPB3115)

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SKU:
RPPB3115
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
CD300A
Synonyms:
CD300a Molecule
Synonyms:
CD300a Antigen
Synonyms:
IRp60
Synonyms:
CD300 Antigen-Like Family Member A
Source:
Escherichia Coli
Uniprot:
Q9UGN4
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Description

Product Name:Human CD300A Recombinant Protein
Product Code:RPPB3115
Size:10µg
Species:Human
Target:CD300A
Synonyms:CD300a Molecule, CD300a Antigen, IRp60, CD300 Antigen-Like Family Member A, NK Inhibitory Receptor, Immunoglobulin Superfamily Member 12, CMRF35-Like Molecule 8, CMRF35-H, Inhibitory Receptor Protein 60, CMRF-35-H9, CMRF-35H, CLM-8, IRC1, IRC2, CMRF35H Leukocyte Immunoglobulin-Like Receptor, Leukocyte Membrane Antigen, IgSF12.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:The CD300A solution contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 1mM DTT and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSLSKCRTV AGPVGGSLSV QCPYEKEHRT LNKYWCRPPQ IFLCDKIVET KGSAGKRNGR VSIRDSPANL SFTVTLENLT EEDAGTYWCG VDTPWLRDFH DPVVEVEVSV FPAS

CD300A belongs to the CD300 family and contains 1 Ig-like V-type (immunoglobulin-like) domain. The protein is expressed not only by natural killer (NK) cells but also by T-cell subsets, B-cells, dendritic cells, mast cells, granulocytes and monocytes. CD300A is inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation.

CD300A Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 134 amino acids (18-128) and having a molecular mass of 14.7kDa.CD300A is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:MAIR-I: Inhibitory receptor which may contribute to the down- regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. Belongs to the CD300 family. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Immunoglobulin superfamily; Membrane protein, integral

Chromosomal Location of Human Ortholog: 17q25.1

Cellular Component: membrane; plasma membrane

Molecular Function:phosphatidylethanolamine binding; phosphatidylserine binding; protein binding

Biological Process: negative regulation of B cell proliferation; negative regulation of B cell receptor signaling pathway; negative regulation of fibroblast proliferation; negative regulation of MAP kinase activity; negative regulation of mast cell activation during immune response; negative regulation of mast cell degranulation; negative regulation of MyD88-dependent toll-like receptor signaling pathway; negative regulation of NK T cell activation; negative regulation of phagocytosis, engulfment; neutrophil degranulation; positive regulation of phosphoprotein phosphatase activity; regulation of immune response; regulation of T cell receptor signaling pathway

NCBI Summary:This gene encodes a member of the CD300 glycoprotein family of cell surface proteins found on leukocytes involved in immune response signaling pathways. This gene is located on chromosome 17 in a cluster with all but one of the other family members. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
UniProt Code:Q9UGN4
NCBI GenInfo Identifier:126302534
NCBI Gene ID:11314
NCBI Accession:Q9UGN4.2
UniProt Secondary Accession:Q9UGN4,O95100, Q9HD97, Q9P0F3, Q9UBK4, Q9UMS9, Q9UMT0 A8MW96,
UniProt Related Accession:Q9UGN4
Molecular Weight:33kDa
NCBI Full Name:CMRF35-like molecule 8
NCBI Synonym Full Names:CD300a molecule
NCBI Official Symbol:CD300A  
NCBI Official Synonym Symbols:IRC1; IRC2; CLM-8; IRp60; IGSF12; CMRF35H; CMRF-35H; CMRF35-H; CMRF35H9; CMRF35-H9; IRC1/IRC2; CMRF-35-H9  
NCBI Protein Information:CMRF35-like molecule 8
UniProt Protein Name:CMRF35-like molecule 8
UniProt Synonym Protein Names:CD300 antigen-like family member A; CMRF-35-H9; CMRF35-H9; CMRF35-H; IRC1/IRC2; Immunoglobulin superfamily member 12; IgSF12; Inhibitory receptor protein 60; IRp60; NK inhibitory receptor; CD_antigen: CD300a
Protein Family:CMRF35-like molecule
UniProt Gene Name:CD300A  
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