Human CD23 Recombinant Protein (RPPB5872)

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SKU:
RPPB5872
Product type:
Recombinant Protein
Size:
5ug
Species:
Human
Target:
CD23
Synonyms:
Low affinity immunoglobulin epsilon Fc receptor isoform a
Synonyms:
BLAST-2
Synonyms:
CD23
Synonyms:
CD23A
Source:
Sf9 Insect cells
Uniprot:
P06734
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Description

Product Name:Human CD23 Recombinant Protein
Product Code:RPPB5872
Size:5µg
Species:Human
Target:CD23
Synonyms:Low affinity immunoglobulin epsilon Fc receptor isoform a, BLAST-2, CD23, CD23A, CLEC4J, FCE2, IGEBF, C-type lectin domain family 4 member J, Immunoglobulin E-binding factor, Lymphocyte IgE receptor.
Source:Sf9 Insect cells
Physical Appearance:Sterile Filtered colorless solution.
Formulation:FCER2 protein solution (0.25mg/ml) contains phosphate buffered saline (pH7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:ADPDTTQSLK QLEERAARNV SQVSKNLESH HGDQMAQKSQ STQISQELEE LRAEQQRLKS QDLELSWNLN GLQADLSSFK SQELNERNEA SDLLERLREE VTKLRMELQV SSGFVCNTCP EKWINFQRKC YYFGKGTKQW VHARYACDDM EGQLVSIHSP EEQDFLTKHA SHTGSWIGLRNLDLKGEFIW VDGSHVDYSN WAPGEPTSRS QGEDCVMMRG SGRWNDAFCD RKLGAWVCDR LATCTPPASE GSAESMGPDS RPDPDGRLPTPSAPLHSHHH HHH

FCER2, or Fc epsilon RII, is a receptor for IgE with low affinity, which is critical to regulation of IgE levels. IgE is an antibody isotype that attached to allergy and resistance to parasites. FCER2 is a C-type lectin, contrary to many of the receptors for antibodies. FCER2 is located on activated macrophages, mature B cells, follicular dendritic cells, platelets and eosinophils.

FCER2 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 283 amino acids (48-321a.a.) and having a molecular mass of 32.0kDa. (Molecular size on SDS-PAGE will appear at approximately 28-40kDa).FCER2 is expressed with a 9 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).
NCBI Summary:The protein encoded by this gene is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
UniProt Code:P06734
NCBI GenInfo Identifier:119862
NCBI Gene ID:2208
NCBI Accession:P06734.1
UniProt Related Accession:P06734
Molecular Weight:
NCBI Full Name:Low affinity immunoglobulin epsilon Fc receptor
NCBI Synonym Full Names:Fc fragment of IgE receptor II
NCBI Official Symbol:FCER2  
NCBI Official Synonym Symbols:CD23; FCE2; CD23A; IGEBF; CLEC4J; BLAST-2  
NCBI Protein Information:low affinity immunoglobulin epsilon Fc receptor
UniProt Protein Name:Low affinity immunoglobulin epsilon Fc receptor
UniProt Synonym Protein Names:BLAST-2; C-type lectin domain family 4 member J; Fc-epsilon-RII; Immunoglobulin E-binding factor; Lymphocyte IgE receptor; CD_antigen: CD23Cleaved into the following 2 chains:Low affinity immunoglobulin epsilon Fc receptor membrane-bound form; Low affinity immunoglobulin epsilon Fc receptor soluble form
UniProt Gene Name:FCER2  
UniProt Entry Name:FCER2_HUMAN
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