Human ACE2 (18-740) Recombinant Protein (RPPB1328)
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주문- SKU:
- RPPB1328
- Product type:
- Recombinant Protein
- Size:
- 5ug
- Species:
- Human
- Target:
- ACE2 (18-740)
- Source:
- HEK293 Cells
- Uniprot:
- Q9BYF1-1
Description
Product Name: | Human ACE2 (18-740) Recombinant Protein |
Product Code: | RPPB1328 |
Size: | 5µg |
Species: | Human |
Target: | ACE2 (18-740) |
Source: | HEK293 Cells |
Physical Appearance: | Sterile Filtered clear solution. |
Formulation: | ACE2 Human protein solution is supplied in 50mM Tris-HCl, pH7.5, and 150mM NaCl and glycerol. |
Stability: | ACE-2 Human Recombinant Protein is shipped on ice packs. Upon arrival, Store at -20°C. |
Purity: | ACE-2 Protein is >90% pure as determined SDS-PAGE. |
Biological Activity: | ACE2 activity was measured by its binding ability in a functional ELISA.The immobilized Recombinant Human ACE2 protein binds to SARS CoV2 Spike protein Receptor Binding Domain at 2ug per ml. |
UniProt Code: | Q9BYF1-1 |
ACE-2 (Angiotensin converting enzyme 2) an enzyme bound to cell membranes in various organs such as intestines arteries , lungs, heart & kidney. ACE2 an entry receptor of SARS coronaviruses as well as SARS-CoV-2,.The coronavirus spike (S) glycoprotein is a class I viral fusion antigen located on the external envelope of the virion that takes part in a critical part in viral infection by identifying host cell receptors and facilitating fusion of the viral and cellular membranes. 2 main domains in coronavirus S1 have been recognized, the N-terminal domain and C-terminal domain. One or the other and/or both S1 domains function as a receptor-binding domain. SARS-CoV + MERS-CoV equally use C-domain to attach their receptors.ACE2 is a type I transmembrane antigen with an extracellular N-terminal domain having the catalytic site and an intracellular C-terminal tail. ACE2 obtains a signal peptide, a transmembrane domain, and a single metalloproteinase active site containing an HEXXH zinc-binding domain. ACE-2 plays a role as a mono-carboxypeptidase which degrades Ang I to produce the nonapeptide Ang 1–9 and Ang II to create the heptapeptide Ang 1–7.
The HEK293 derived ACE2 Human recombinant protein contains the amino acids 18-740 fused to His-AVI tag at C-terminal. ACE2 Protein binds to SARS Coronavirus-2 [ CoV-2019 ] Spike receptor binding domain.