Human 4-1BBR Recombinant Protein (RPPB0985)
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주문- SKU:
- RPPB0985
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Human
- Target:
- 4-1BBR
- Synonyms:
- Tumor Necrosis Factor Receptor Superfamily
- Synonyms:
- Member 9
- Synonyms:
- T-CellAntigen 4-1BB Homolog
- Synonyms:
- 4-1BB Ligand Receptor
- Source:
- Sf9 Insect cells
- Uniprot:
- Q07011
Description
| Product Name: | Human 4-1BBR Recombinant Protein |
| Product Code: | RPPB0985 |
| Size: | 10µg |
| Species: | Human |
| Target: | 4-1BBR |
| Synonyms: | Tumor Necrosis Factor Receptor Superfamily, Member 9, T-CellAntigen 4-1BB Homolog, 4-1BB Ligand Receptor, T-Cell Antigen ILA, CD137 Antigen,CDw137, CD137, ILA, Interleukin-Activated Receptor, Homolog Of Mouse Ly63, InducedBy Lymphocyte Activation (ILA), Homolog Of Mouse 4-1BB, Receptor Protein 4-1BB,T Cell Antigen ILA, 4-1BB, Tumor necrosis factor receptor superfamily member 9. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | 4-1BBRprotein solution (0.5mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10%glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE |
| Amino Acid Sequence: | ADLFERTRSLQDPCSNCPAG TFCDNNRNQI CSPCPPNSFS SAGGQRTCDI CRQCKGVFRT RKECSSTSNA ECDCTPGFHCLGAGCSMCEQ DCKQGQELTK KGCKDCCFGT FNDQKRGICR PWTNCSLDGK SVLVNGTKER DVVCGPSPADLSPGASSVTP PAPAREPGHS PQLEPKSCDKTHTCPPCPAP ELLGGPSVFL FPPKPKDTLM ISRTPEVTCV VVDVSHEDPEVKFNWYVDGV EVHNAKTKPR EEQYNSTYRV VSVLTVLHQD WLNGKEYKCK VSNKALPAPI EKTISKAKGQPREPQVYTLP PSRDELTKNQ VSLTCLVKGF YPSDIAVEWE SNGQPENNYK TTPPVLDSDGSFFLYSKLTV DKSRWQQGNV FSCSVMHEAL HNHYTQKSLS LSPGKHHHHH H |
4-1BBR is a member of the TNF-receptor superfamily.4-1BB receptor contributes to the clonal expansion, survival, and development of T cells.4-1BBRcan also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB.
4-1BBR produced in Sf9 Baculovirus cells is a single,glycosylated polypeptide chain containing 411 amino acids (18-186a.a.) andhaving a molecular mass of 45.3kDa. (Molecular size on SDS-PAGE will appear atapproximately 40-57kDa).4-1BBR is expressed with a 242 amino acid hIgG-His-tag atC-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | TNFRSF9: Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 1p36 Cellular Component: extracellular space; integral to plasma membrane; external side of plasma membrane Molecular Function:cytokine binding; receptor activity Biological Process: negative regulation of cell proliferation; apoptosis |
| NCBI Summary: | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q07011 |
| NCBI GenInfo Identifier: | 728738 |
| NCBI Gene ID: | 3604 |
| NCBI Accession: | Q07011.1 |
| UniProt Related Accession: | Q07011,AAB34924 |
| Molecular Weight: | 27,899 Da |
| NCBI Full Name: | Tumor necrosis factor receptor superfamily member 9 |
| NCBI Synonym Full Names: | tumor necrosis factor receptor superfamily, member 9 |
| NCBI Official Symbol: | TNFRSF9 |
| NCBI Official Synonym Symbols: | ILA; 4-1BB; CD137; CDw137 |
| NCBI Protein Information: | tumor necrosis factor receptor superfamily member 9; CD137 antigen; T cell antigen ILA; T-cell antigen ILA; 4-1BB ligand receptor; homolog of mouse 4-1BB; receptor protein 4-1BB; T-cell antigen 4-1BB homolog; induced by lymphocyte activation (ILA); interleukin-activated receptor, homolog of mouse Ly63 |
| UniProt Protein Name: | Tumor necrosis factor receptor superfamily member 9 |
| UniProt Synonym Protein Names: | 4-1BB ligand receptor; CDw137; T-cell antigen 4-1BB homolog; T-cell antigen ILA; CD_antigen: CD137 |
| UniProt Gene Name: | TNFRSF9 |
| UniProt Entry Name: | TNR9_HUMAN |
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