Glutamate / Excitotoxicity Antibody Sampler Pack

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SKU:
ABSP040
Product Type:
Antibody
Size:
Antibody Sampler Pack
Size:
8 X 20μL
Reactivity:
Human
Mouse
Rat
Analytes:
NMDAR1/GRIN1
NMDAR2B/GRIN2B
GluA1/GRIA1
mGluR5/GRM5
CaMKII
Phospho-CaMKII
EAAT2/GLT-1
GAD67
  • Anti-NMDAR1 [ARC0684] Monoclonal Antibody (CAB11699)
  • Anti-GRIN2B Antibody (CAB3056)
  • Anti-GluR1/GRIA1 [ARC0657] Monoclonal Antibody (CAB11643)
  • Anti-GRM5 [ARC0250] Monoclonal Antibody (CAB3758)
  • Anti-CaMKII [ARC53334] Monoclonal Antibody (CAB0186)
  • Anti-Phospho-Camk2a-T286 Antibody (CABP0255)
  • Anti-EAAT2/SLC1A2 Antibody (CAB0910)
  • Anti-GAD67/GAD1 [ARC1879] Monoclonal Antibody (CAB1475)

Description

Glutamate / Excitotoxicity Antibody Sampler Pack

The Glutamate / Excitotoxicity Antibody Sampler Pack from Assay Genie brings together 8 rigorously validated antibodies spanning the key nodes of this pathway, supplied in a convenient 20µL trial size. It lets researchers screen an entire signalling axis in a single, cost-effective pack — validated for applications including ELISA, IF/ICC, IP, WB — before committing to full-size vials. Each antibody is also available individually in a full 100µL size.

TargetAntibodyCat. No.HostReactivityApplicationsSize
NMDAR1/GRIN1Anti-NMDAR1 [ARC0684] Monoclonal AntibodyCAB11699-20RabbitMouse, RatWBIF/ICCELISA20µL
NMDAR2B/GRIN2BAnti-GRIN2B AntibodyCAB3056-20RabbitHuman, Mouse, RatWBIF/ICCELISA20µL
GluA1/GRIA1Anti-GluR1/GRIA1 [ARC0657] Monoclonal AntibodyCAB11643-20RabbitMouse, RatWBELISA20µL
mGluR5/GRM5Anti-GRM5 [ARC0250] Monoclonal AntibodyCAB3758-20RabbitMouse, RatWBELISA20µL
CaMKIIAnti-CaMKII [ARC53334] Monoclonal AntibodyCAB0186-20RabbitHuman, Mouse, RatWBIPELISA20µL
Phospho-CaMKIIAnti-Phospho-Camk2a-T286 AntibodyCABP0255-20RabbitHuman, Mouse, RatWBELISA20µL
EAAT2/GLT-1Anti-EAAT2/SLC1A2 AntibodyCAB0910-20RabbitMouse, RatWBIF/ICCELISA20µL
GAD67Anti-GAD67/GAD1 [ARC1879] Monoclonal AntibodyCAB1475-20RabbitHuman, Mouse, RatWBELISA20µL

Glutamate is the principal excitatory neurotransmitter of the central nervous system, and the same signaling that underlies synaptic plasticity becomes destructive when glutamate accumulates excessively, a process termed excitotoxicity that contributes to stroke, traumatic injury, epilepsy, and chronic neurodegeneration. Fast excitatory transmission and plasticity are mediated by ionotropic glutamate receptors. The NMDA receptor, an obligate heteromer, includes the essential subunit NMDAR1/GRIN1 together with regulatory subunits such as NMDAR2B/GRIN2B, which confers slow kinetics and high calcium permeability and is strongly implicated in excitotoxic calcium overload. AMPA receptors mediate the bulk of rapid depolarization, and their subunit GluA1/GRIA1 is dynamically trafficked to and from synapses during long-term potentiation. Metabotropic signaling through mGluR5/GRM5 couples glutamate to intracellular calcium release and modulates synaptic strength and excitability. A key decoder of the resulting calcium signals is CaMKII, a kinase that, upon autophosphorylation to Phospho-CaMKII, becomes persistently active and drives the synaptic changes that consolidate memory, while excessive activation participates in excitotoxic injury. The magnitude and duration of glutamate signaling are constrained by clearance and by inhibitory balance. EAAT2/GLT-1, the dominant astrocytic glutamate transporter, removes synaptic glutamate to terminate transmission and prevent toxic accumulation, and its dysfunction is a recognized contributor to excitotoxic disease. Inhibitory tone that opposes excitation depends on GABA synthesis by GAD67, the glutamate decarboxylase isoform that sets baseline GABA levels. Together these targets span receptor signaling, calcium decoding, transporter-mediated clearance, and excitatory-inhibitory balance. This pack brings together validated antibodies against NMDAR1/GRIN1, NMDAR2B/GRIN2B, GluA1/GRIA1, mGluR5/GRM5, CaMKII, Phospho-CaMKII, EAAT2/GLT-1, and GAD67 to support study of glutamatergic signaling and excitotoxicity.

AnalyteAlternate Names
NMDAR1/GRIN1GRIN1, NMDAR1, NR1, Glutamate receptor ionotropic NMDA 1, NMDA1
NMDAR2B/GRIN2BGRIN2B, NMDAR2B, NR2B, Glutamate receptor ionotropic NMDA 2B
GluA1/GRIA1GRIA1, GluA1, GluR1, AMPA receptor subunit 1, GLUR1
mGluR5/GRM5GRM5, mGluR5, Metabotropic glutamate receptor 5, GPRC1E
CaMKIICAMK2A, CAMK2B, CAMK2D, CAMK2G, Ca2+/calmodulin-dependent protein kinase II
Phospho-CaMKIICAMK2A, CaMKII (phospho-Thr286)
EAAT2/GLT-1SLC1A2, EAAT2, GLT-1, Excitatory amino acid transporter 2
GAD67GAD1, Glutamate decarboxylase 1, GAD67
SpecificationDetail
Pack Format8 antibodies, 20µL each (trial size)
StorageStore at -20°C upon receipt
Shelf Life12 months from date of receipt
ShippingGel pack
Scale-upEvery antibody is also available individually in a full 100µL size

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