The Gephyrin Monoclonal Antibody (CAB4729) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, generated from rabbit hosts, is highly specific to human samples and has been extensively validated for use in Western blot applications. By binding to gephyrin, this antibody enables precise detection and analysis of this crucial protein in various cell types, making it an essential tool for neuroscience and neurology research. Gephyrin is a scaffolding protein that plays a vital role in the clustering and anchoring of inhibitory neurotransmitter receptors at synapses in the central nervous system. Dysregulation of gephyrin has been implicated in various neurological disorders, including epilepsy, autism, and schizophrenia.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.
Product Name:
Gephyrin Monoclonal Antibody
SKU:
CAB4729
Size:
20μL, 100μL
Reactivity:
Human, Mouse, Rat
Clone Number:
ARC1109
Conjugate:
Unconjugated
Immunogen:
Synthetic peptide. This information is considered to be commercially sensitive.
This gene encodes a neuronal assembly protein that anchors inhibitory neurotransmitter receptors to the postsynaptic cytoskeleton via high affinity binding to a receptor subunit domain and tubulin dimers. In nonneuronal tissues, the encoded protein is also required for molybdenum cofactor biosynthesis. Mutations in this gene may be associated with the neurological condition hyperplexia and also lead to molybdenum cofactor deficiency. Numerous alternatively spliced transcript variants encoding different isoforms have been described; however, the full-length nature of all transcript variants is not currently known.
Purification Method
Affinity purification
Gene ID
10243
RRID
AB_2863333
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates using Gephyrin Rabbit mAb (CAB4729) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 10s.
Western blot analysis of various lysates using Gephyrin Rabbit mAb (CAB4729) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 3min.
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