The EXOC2 Monoclonal Antibody (CAB23562) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced through hybridoma technology, specifically targets EXOC2 in human samples and is validated for use in various applications such as immunofluorescence and immunohistochemistry.EXOC2 plays a crucial role in regulating vesicle docking and fusion at the plasma membrane, making it essential for cellular secretion processes in various cell types. Dysregulation of EXOC2 has been linked to disorders such as cancer, neurodegenerative diseases, and diabetes, highlighting its importance in cellular function and disease pathology.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.
Product Name:
EXOC2 Monoclonal Antibody
SKU:
CAB23562
Size:
20μL, 100μL
Reactivity:
Human, Mouse, Rat
Clone Number:
ARC3126
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:
Email for sequence
Tested Applications:
WBELISA
Recommended Dilution:
WB
1:1000 - 1:2000
ELISA
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:
SEC5, Sec5p, SEC5L1, NEDFACH, EXOC2
Positive Sample:
K-562
Calculated MW:
104kDa
Observed MW:
104kDa
The protein encoded by this gene is a component of the exocyst complex, a multi-protein complex essential for the polarized targeting of exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and the functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. This interaction has been shown to mediate filopodia formation in fibroblasts. This protein has been shown to interact with the Ral subfamily of GTPases and thereby mediate exocytosis by tethering vesicles to the plasma membrane. Alternative splicing results in multiple transcript variants.
Purification Method
Affinity purification
Gene ID
55770
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of lysates from K-562 cells using EXOC2 Rabbit mAb (CAB23562) at 1:2000 dilution incubated at room temperature for 1.5 hours. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25 μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 90 s.
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