Cytokine Signaling (TNF/IL) Antibody Sampler Pack

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SKU:
ABSP026
Product Type:
Antibody
Size:
Antibody Sampler Pack
Size:
8 X 20μL
Reactivity:
Human
Mouse
Rat
Analytes:
TNF-alpha
IL-6
IL-1beta
IL-10
TNFR1
IL-6R
TGF-beta
IFN-gamma
  • Anti-TNF-alpha [ARC52538] Monoclonal Antibody (CAB21265)
  • Anti-IL6 [ARC5093-01] Monoclonal Antibody (CAB22222)
  • Anti-IL1beta [ARC56180] Monoclonal Antibody (CAB22257)
  • Anti-IL10 Monoclonal Antibody (CAB12255)
  • Anti-TNFR1/TNFRSF1A Antibody (CAB1540)
  • Anti-IL6R Antibody (CAB1570)
  • Anti-TGFB1 Antibody (CAB15103)
  • Anti-IFNG Antibody (CAB0242)

Description

Cytokine Signaling (TNF/IL) Antibody Sampler Pack

The Cytokine Signaling (TNF/IL) Antibody Sampler Pack from Assay Genie brings together 8 rigorously validated antibodies spanning the key nodes of this pathway, supplied in a convenient 20µL trial size. It lets researchers screen an entire signalling axis in a single, cost-effective pack — validated for applications including ELISA, IF/ICC, IHC-P, WB — before committing to full-size vials. Each antibody is also available individually in a full 100µL size.

TargetAntibodyCat. No.HostReactivityApplicationsSize
TNF-alphaAnti-TNF-alpha [ARC52538] Monoclonal AntibodyCAB21265-20RabbitHumanIHC-PELISA20µL
IL-6Anti-IL6 [ARC5093-01] Monoclonal AntibodyCAB22222-20RabbitHumanWBELISA20µL
IL-1betaAnti-IL1beta [ARC56180] Monoclonal AntibodyCAB22257-20RabbitMouseWBELISA20µL
IL-10Anti-IL10 Monoclonal AntibodyCAB12255-20RabbitHuman, RatWBELISA20µL
TNFR1Anti-TNFR1/TNFRSF1A AntibodyCAB1540-20RabbitHuman, Mouse, RatWBIHC-PIF/ICCELISA20µL
IL-6RAnti-IL6R AntibodyCAB1570-20RabbitHuman, Mouse, RatWBIHC-PELISA20µL
TGF-betaAnti-TGFB1 AntibodyCAB15103-20RabbitHuman, Mouse, RatIF/ICCELISA20µL
IFN-gammaAnti-IFNG AntibodyCAB0242-20RabbitHumanWBELISA20µL

Cytokines are secreted signaling proteins that coordinate the initiation, amplification, and resolution of immune and inflammatory responses by acting on specific cell-surface receptors. The balance between proinflammatory and anti-inflammatory cytokines determines whether an immune response clears a threat and resolves or progresses to chronic inflammation and tissue damage. Tumor necrosis factor alpha (TNF-alpha) is a master proinflammatory cytokine that signals through TNFR1 to activate NF-kB and MAP kinase cascades, inducing inflammatory gene expression, and under certain conditions can trigger apoptosis or necroptosis. IL-6 is a pleiotropic cytokine driving the acute-phase response, fever, and lymphocyte differentiation; it signals through the IL-6R and the shared gp130 chain to activate JAK-STAT3 signaling and is a major target in inflammatory and autoimmune disease. IL-1beta, processed and released following inflammasome activation, is a powerful pyrogen that amplifies local and systemic inflammation. Counterbalancing these signals, IL-10 is a key immunosuppressive cytokine that restrains macrophage and dendritic cell activation to limit immunopathology, and TGF-beta exerts broad context-dependent regulatory effects on cell growth, fibrosis, and the differentiation of regulatory and Th17 cells. IFN-gamma, produced chiefly by Th1 cells and NK cells, activates macrophages, upregulates antigen presentation, and reinforces cell-mediated immunity. The integrated output of these networks shapes the pathogenesis of autoimmunity, infection, fibrosis, and cancer, and many cytokines and their receptors are validated therapeutic targets. Measuring cytokine ligands alongside their receptors enables study of signaling at both ends of the axis. This sampler pack brings together validated antibodies against TNF-alpha, IL-6, IL-1beta, IL-10, TNFR1, IL-6R, TGF-beta, and IFN-gamma for studying cytokine networks in immunity and inflammation.

AnalyteAlternate Names
TNF-alphaTNF, Tumor necrosis factor, TNFA, TNFSF2, Cachectin
IL-6Interleukin-6, BSF2, IFNB2, B-cell stimulatory factor 2
IL-1betaIL1B, Interleukin-1 beta, IL-1F2, Catabolin
IL-10Interleukin-10, CSIF, Cytokine synthesis inhibitory factor
TNFR1TNFRSF1A, TNFR1, CD120a, p55, TNF receptor superfamily member 1A
IL-6RIL6R, Interleukin-6 receptor, CD126, IL-6RA, gp80
TGF-betaTGFB1, Transforming growth factor beta-1, TGF-beta-1, CED
IFN-gammaIFNG, Interferon gamma, IFN-g, Type II interferon
SpecificationDetail
Pack Format8 antibodies, 20µL each (trial size)
StorageStore at -20°C upon receipt
Shelf Life12 months from date of receipt
ShippingGel pack
Scale-upEvery antibody is also available individually in a full 100µL size

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