Claudin 6 Monoclonal Antibody (CAB24011)

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SKU:
CAB24011
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
Reactivity:
Human, Mouse, Rat

Description

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Claudin 6 Monoclonal Antibody (CAB24011)

The Claudin 6 Monoclonal Antibody (CAB24011) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced using cutting-edge monoclonal antibody technology, specifically targets Claudin-6 in human samples and is suitable for various research applications, including immunofluorescence, immunohistochemistry, and flow cytometry.Claudin-6 is a critical component of tight junctions, which are essential for maintaining the integrity of epithelial barriers in various tissues. Dysregulation of Claudin-6 has been linked to various diseases, including cancer and inflammatory disorders.

This antibody is validated for use in WB, IHC-P, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.

Product Name:Claudin 6 Monoclonal Antibody
SKU:CAB24011
Size:20μL, 100μL
Reactivity:Human, Mouse, Rat
Clone Number:ARC63026
Conjugate:Unconjugated
Immunogen:Synthetic peptide. This information is considered to be commercially sensitive.
Sequence:SGIV FVIS GVLT LIPV CWTA HAII RDFY NPLV AEAQ KREL GASL YLGW AASG LLLL GGGL LCCT CPSG GSQG PSHY MARY STSA PAIS RGPS EYPT KNYV
Tested Applications:WB IHC-P ELISA
Recommended Dilution:
WB1:3000 - 1:12000
IHC-P1:500 - 1:1000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Positive Sample:Hep G2, OVCAR-3, Mouse placenta, Rat kidney
Cellular Localization:Apicolateral Plasma Membrane, Bicellular Tight Junction, Plasma Membrane.
Calculated MW:23kDa
Observed MW:22kDa

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.

Purification MethodAffinity purification
Gene ID9074
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of various lysates, using Claudin 6 Rabbit mAb (CAB24011) at 1:3000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 15s.
Product ImageWestern blot analysis of various lysates, using Claudin 6 Rabbit mAb (CAB24011) at 1:3000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 45s.

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