Cellular Senescence Antibody Sampler Pack

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SKU:
ABSP017
Product Type:
Antibody
Size:
Antibody Sampler Pack
Size:
8 X 20μL
Reactivity:
Human
Mouse
Rat
Analytes:
p16 INK4A
p21
p53
Lamin B1
Rb
HMGB1
IL-6
p38 MAPK
  • Anti-CDKN2A/p16INK4a [ARC0661] Monoclonal Antibody -Knockout Validated (CAB11651)
  • Anti-CDKN1A Antibody (CAB20471)
  • Anti-p53 DINP1 [ARC2102] Monoclonal Antibody (CAB5952)
  • Anti-Lamin B1 Antibody -Knockout Validated (CAB1910)
  • Anti-RB Monoclonal Antibody (CAB3618)
  • Anti-Acetyl-HMGB1-K29 Antibody -Knockout Validated (CAB16002)
  • Anti-IL6 [ARC5093-01] Monoclonal Antibody (CAB22222)
  • Anti-p38 MAPK Antibody -Knockout Validated (CAB14401)

Description

Cellular Senescence Antibody Sampler Pack

The Cellular Senescence Antibody Sampler Pack from Assay Genie brings together 8 rigorously validated antibodies spanning the key nodes of this pathway, supplied in a convenient 20µL trial size. It lets researchers screen an entire signalling axis in a single, cost-effective pack — validated for applications including ChIP, ELISA, IF/ICC, IHC-P, IP, WB — before committing to full-size vials. Each antibody is also available individually in a full 100µL size.

TargetAntibodyCat. No.HostReactivityApplicationsSize
p16 INK4AAnti-CDKN2A/p16INK4a [ARC0661] Monoclonal Antibody -Knockout ValidatedCAB11651-20RabbitHumanWBIHC-PIF/ICCELISA20µL
p21Anti-CDKN1A AntibodyCAB20471-20RabbitMouse, RatWBELISA20µL
p53Anti-p53 DINP1 [ARC2102] Monoclonal AntibodyCAB5952-20RabbitHuman, Mouse, RatWBIHC-PIF/ICCELISA20µL
Lamin B1Anti-Lamin B1 Antibody -Knockout ValidatedCAB1910-20RabbitHuman, Mouse, RatWBIHC-PIF/ICCIPChIPELISA20µL
RbAnti-RB Monoclonal AntibodyCAB3618-20RabbitHumanIF/ICCELISA20µL
HMGB1Anti-Acetyl-HMGB1-K29 Antibody -Knockout ValidatedCAB16002-20RabbitHuman, Mouse, RatWBIF/ICCELISA20µL
IL-6Anti-IL6 [ARC5093-01] Monoclonal AntibodyCAB22222-20RabbitHumanWBELISA20µL
p38 MAPKAnti-p38 MAPK Antibody -Knockout ValidatedCAB14401-20RabbitHuman, Mouse, RatWBIHC-PIF/ICCIPELISA20µL

Cellular senescence is a state of stable, essentially irreversible cell-cycle arrest triggered by telomere attrition, oncogene activation, DNA damage, and other stresses. It acts as a potent barrier to tumorigenesis by withdrawing damaged or oncogene-bearing cells from the proliferative pool, yet senescent cells persist metabolically active and can paradoxically promote tissue dysfunction and tumor progression through their secretory phenotype. The arrest is enforced principally by two tumor suppressor axes. The CDK inhibitor p16 INK4A blocks CDK4/6 activity to maintain the retinoblastoma protein Rb in its active, hypophosphorylated state, where Rb represses E2F-driven proliferative genes and stably locks cells out of the cycle. In parallel, the p53 pathway induces the CDK inhibitor p21 to establish and reinforce arrest in response to damage signals. A hallmark of the senescent nucleus is the loss of the nuclear lamina protein Lamin B1, whose downregulation accompanies chromatin reorganization and is a reliable senescence marker. Senescent cells also acquire a senescence-associated secretory phenotype, releasing inflammatory mediators such as IL-6 and the alarmin HMGB1, which relocalizes from the nucleus to the extracellular space; this secretome reinforces arrest locally but can remodel the tissue microenvironment, promote inflammation, and in some settings drive proliferation and immune evasion of neighboring tumor cells. Stress kinase signaling through p38 MAPK contributes to both arrest establishment and the secretory program. In cancer, senescence underlies therapy-induced growth arrest but also contributes to relapse and age-associated tumor risk, motivating senolytic strategies. Profiling these effectors distinguishes genuine senescence from quiescence and characterizes the secretory program. This pack brings together validated antibodies against p16 INK4A, p21, p53, Lamin B1, Rb, HMGB1, IL-6, and p38 MAPK for studying cellular senescence.

AnalyteAlternate Names
p16 INK4ACDKN2A, p16, INK4A, p16INK4a, Cyclin-dependent kinase inhibitor 2A, MTS1
p21CDKN1A, p21, WAF1, CIP1, Cyclin-dependent kinase inhibitor 1
p53TP53, Tumor protein p53, p53
Lamin B1LMNB1, Lamin-B1
RbRB1, Retinoblastoma protein, pRb, p105-Rb
HMGB1High mobility group box 1, HMG1, Amphoterin
IL-6Interleukin-6, BSF2, IFNB2, B-cell stimulatory factor 2
p38 MAPKMAPK14, p38, p38-alpha, CSBP, SAPK2A
SpecificationDetail
Pack Format8 antibodies, 20µL each (trial size)
StorageStore at -20°C upon receipt
Shelf Life12 months from date of receipt
ShippingGel pack
Scale-upEvery antibody is also available individually in a full 100µL size

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