c-Abl Monoclonal Antibody (CAB22082)

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SKU:
CAB22082
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
Synonyms:
ABL, JTK7, p150, c-ABL, v-abl, CHDSKM, c-ABL1, BCR-ABL, bcr/abl, c-Abl

Description

system_update_altDatasheetsystem_update_altMSDS

c-Abl Monoclonal Antibody (CAB22082)

The c-Abl Monoclonal Antibody (CAB22082) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced by Assay Genie, specifically targets the C-ABL protein, a tyrosine kinase involved in cell growth, division, and differentiation.With its high specificity and sensitivity, the CAB22082 antibody is suitable for a range of applications, including Western blotting, immunohistochemistry, and flow cytometry. It has been validated for use with human samples, ensuring reliable and reproducible results in research studies.The C-ABL protein is known to play a critical role in signaling pathways that regulate cell proliferation and survival.

This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human samples.

Product Name:c-Abl Monoclonal Antibody
SKU:CAB22082
Size:20μL, 100μL
Reactivity:Human
Clone Number:ARC55104
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:TAFI PLIS TRVS LRKT RQPP ERIA SGAI TKGV VLDS TEAL CLAI SRNS EQMA SHSA VLEA GKNL YTFC VSYV DSIQ QMRN KFAF REAI NKLE NNLR ELQI CPAT AGSG PAAT QDFS KLLS SVKE ISDI VQR
Tested Applications:WB ELISA
Recommended Dilution:
WB1:1000 - 1:5000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:ABL, JTK7, p150, c-ABL, v-abl, CHDSKM, c-ABL1, BCR-ABL, bcr/abl, c-Abl
Positive Sample:K-562
Cellular Localization:Cytoplasm, Lipid-Anchor, Mitochondrion, Nucleus, Nucleus Membrane, Cytoskeleton.
Calculated MW:123kDa
Observed MW:210kDa

This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons.

Purification MethodAffinity purification
Gene ID25
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.09% Sodium azide,0.05% BSA,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from K-562 cells using c-Abl Rabbit mAb (CAB22082) at 1:5000 dilution incubated overnight at 4℃. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25 μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 45s.

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