The Bovine Transforming Growth Factor Beta 2 (TGFB2) ELISA Kit is specifically designed for the quantitative detection of TGFB2 levels in bovine serum, plasma, and tissue homogenates. This kit offers exceptional sensitivity and specificity, ensuring accurate and reproducible results for a variety of research applications.TGFB2 is a key regulatory protein involved in cell growth, differentiation, and immune response. It plays a critical role in various biological processes, including embryonic development, tissue repair, and immune modulation.
Dysregulation of TGFB2 has been linked to various diseases such as cancer, fibrosis, and autoimmune disorders, highlighting its importance as a potential therapeutic target.With its high-performance features, the Bovine TGFB2 ELISA Kit is an invaluable tool for researchers studying the role of TGFB2 in disease pathogenesis and therapeutic development. Its reliable performance and ease of use make it a valuable asset in advancing scientific knowledge and innovation in the field of molecular biology and medicine.
Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains remain non-covalently linked rendering TGF-beta-2 inactive during storage in extracellular matrix (By similarity). At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2 and maintain it in a latent state during storage in extracellular milieus (By similarity). Once activated following release of LAP, TGF-beta-2 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal (By similarity).
Uniprot:
P21214
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Specificity:
Natural and recombinant bovine Transforming growth factor beta-2 proprotein
Sub Unit:
Interacts with the serine proteases, HTRA1 and HTRA3 (By similarity). Interacts with ASPN (By similarity). Interacts with MFAP5 (By similarity). Latency-associated peptide: Interacts with Transforming growth factor beta-2 (TGF-beta-2) chain; interaction is non-covalent and maintains (TGF-beta-2) in a latent state (By similarity). Latency-associated peptide: Interacts with LRRC32/GARP; leading to regulate activation of TGF-beta-2 (By similarity). Latency-associated peptide: Interacts with NREP; the interaction results in a decrease in TGFB2 autoinduction (By similarity). Transforming growth factor beta-2: Homodimer; disulfide-linked (By similarity). Transforming growth factor beta-2: Interacts with TGF-beta receptors (TGFBR1 and TGFBR2), leading to signal transduction (By similarity).
